{"id":9523,"date":"2023-01-11T09:33:00","date_gmt":"2023-01-11T01:33:00","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=9523"},"modified":"2023-09-26T10:23:28","modified_gmt":"2023-09-26T02:23:28","slug":"%e6%8f%90%e5%8d%87%e7%a0%94%e7%a9%b6%e8%83%bd%e9%87%8f%e7%b3%bb%e5%88%97%e8%ac%9b%e5%ba%a7-%e6%85%88%e5%a4%a7%e9%86%ab%e7%a7%91%e6%89%80%e9%82%80%e4%b8%ad%e7%a0%94%e9%99%a2%e5%be%90%e9%ba%97%e8%8a%ac","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=9523","title":{"rendered":"\u63d0\u5347\u7814\u7a76\u80fd\u91cf\u7cfb\u5217\u8b1b\u5ea7 \u6148\u5927\u91ab\u79d1\u6240\u9080\u4e2d\u7814\u9662\u5f90\u9e97\u82ac\u7279\u8058\u7814\u7a76\u54e1\u5206\u4eab"},"content":{"rendered":"

\u6587<\/span>\/<\/span>\u7167\u7247\uff1a\u6d2a\u9038\u5b89<\/span><\/p>\n

\u5f9e\u96f6\u958b\u59cb\u7684\u8349\u85e5\u7814\u7a76\uff0c\u7d93\u904e<\/span>20<\/span>\u5e74\u7684\u5c08\u7cbe\u8983\u601d\uff0c\u4e26\u65bc<\/span>2020<\/span>\u5e74\u69ae\u7372\u570b\u5bb6\u65b0\u5275\u7cbe\u9032\u734e\uff0c\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u535a\u58eb\u73ed\u975e\u5e38\u69ae\u5e78\u9080\u8acb\u5230\u4e2d\u592e\u7814\u7a76\u9662\u5f90\u9e97\u82ac\u535a\u58eb\u5206\u4eab\u4e3b\u984c<\/span>\u201c From bench top to bedside: Formosan Herbal Medicine R&D for Cancer Diseases\u201d<\/span>\u3002<\/span><\/p>\n

\u5f90\u9e97\u82ac\u535a\u58eb\u76ee\u524d\u70ba\u4e2d\u592e\u7814\u7a76\u9662\u8fb2\u696d\u751f\u7269\u79d1\u6280\u7814\u7a76\u4e2d\u5fc3\u7279\u8058\u7814\u7a76\u54e1\uff0c\u81f4\u529b\u65bc\u8349\u85e5\u79d1\u5b78\u61c9\u7528\u5728\u6297<\/span>(<\/span>\u9632<\/span>)<\/span>\u764c\u7684\u76f8\u95dc\u7814\u7a76\uff0c\u81f3\u4eca\u5df2\u767c\u8868\u4e86\u8d85\u904e\u767e\u7bc7\u4ee5\u4e0a\u76f8\u95dc\u6587\u7ae0\u65bc\u570b\u969b\u5b78\u8853\u671f\u520a\uff0c\u7814\u7a76\u65b9\u5411\u5206\u70ba\u5169\u5927\u985e\uff0c\u5206\u5225\u662f\uff1a\u6297\u767c\u708e\u85e5\u7528\u690d\u7269\u4e4b\u6297<\/span>( <\/span>\u9632<\/span>) <\/span>\u764c\u66a8\u4ee3\u8b1d\u7522\u7269\u9ad4\u5b78\u7814\u7a76\u8207\u9175\u7d20\u4e4b\u86cb\u767d\u8cea\u5de5\u7a0b\u7814\u7a76\u5728\u8fb2\u696d\u751f\u7269\u79d1\u6280\u4e4b\u61c9\u7528\u3002\u76ee\u524d\u7814\u7a76\u767c\u73fe\u6297\u764c\u85e5\u7269\u4e3b\u8981\u6210\u5206\u5927\u591a\u5f9e\u5929\u7136\u690d\u7269\u4e2d\u8403\u53d6\u800c\u5f97\uff0c\u6291\u6216\u662f\u6216\u5c07\u5176\u52a0\u4ee5\u6539\u9020\u6210\u76f8\u95dc\u985e\u4f3c\u7269\uff0c\u5982\u592a\u5e73\u6d0b\u7d2b\u6749\u9187<\/span> (paclitaxel)<\/span>\u53ef\u7528\u65bc\u6cbb\u7642\u4e73\u764c\u3001\u5375\u5de2\u764c\uff1b\u5f37\u9ad4\u677e\uff08<\/span>prednisone<\/span>\uff09\u7528\u65bc\u6cbb\u7642\u665a\u671f\u524d\u5217\u817a\u764c\u3002\u9452\u6b64\uff0c\u9e97\u82ac\u6559\u6388\u81f4\u529b\u65bc\u5f9e\u53f0\u7063\u4e2d\u8349\u85e5\u4e2d\u5c0b\u627e\u5929\u7136\u6297\u764c\u6210\u5206\u5316\u5408\u7269\uff0c\u671f\u671b\u964d\u4f4e\u6cbb\u7642\u526f\u4f5c\u7528\u4e26\u53ef\u5354\u52a9\u6cbb\u7642\u589e\u5f37\u7642\u6548\uff0c\u56e0\u6b64\u9e97\u82ac\u8001\u5e2b\u671f\u671b\u5f9e\u53f0\u7063\u5e38\u898b\u7684\u4e2d\u8349\u85e5\u4e2d\u627e\u51fa\u5929\u7136\u7269\u4e2d\u5177\u6709\u6297\u764c\u8207\u9632\u764c\u7684\u5316\u5408\u7269\uff0c\u4ee5\u964d\u4f4e\u50b3\u7d71\u85e5\u7269\u6cbb\u7642\u7684\u526f\u4f5c\u7528\u3001\u4ee5\u53ca\u5177\u6709\u52a0\u4e58\u5354\u52a9\u6cbb\u7642\u7684\u6548\u679c\uff0c\u4f5c\u70ba\u8f14\u4f50\u5316\u7642\u7684\u89d2\u8272\u3002\u6c11\u9593\u6240\u6d41\u50b3\u6709\u6548\u7684\u4e2d\u8349\u85e5\u5177\u6709\u6297\u767c\u708e\u8207\u6d88\u6bd2\u7684\u4f5c\u7528\uff0c\u4e0d\u904e\u591a\u70ba\u53e3\u8033\u76f8\u50b3\uff0c\u5229\u7528\u79d1\u5b78\u7684\u65b9\u5f0f\u540c\u6642\u4e5f\u53ef\u4ee5\u9a57\u8b49\u53e4\u4eba\u7684\u667a\u6167\u3002<\/span><\/p>\n

\u9e97\u82ac\u8001\u5e2b\u7814\u7a76\u5ba4\u767c\u73fe\u662d\u548c\u8349\u4e2d\u7684\u6d3b\u6027\u6210\u5206<\/span>1,2-<\/span>\u4e8c<\/span>-O-\u03b1-<\/span>\u6b21\u4e9e\u9ebb\u6cb9\u91af\u57fa<\/span>-3-O-\u03b2-<\/span>\u534a\u4e73\u7cd6\u5421\u5583\u7cd6\u57fa<\/span>-sn-<\/span>\u7518\u6cb9<\/span>(1,2-di-O-<\/span> \u03b1-linolenoyl-3-O- \u03b2-galacto-pyranosyl-sn-glycerol, dLGG)<\/span>\uff0c\u53ef\u4ee5\u9810\u9632\u731b\u7206\u6027\u809d\u708e\u3001\u6cbb\u7642\u6216\u9810\u9632\u7d30\u83cc\u6216\u75c5\u6bd2\u5f15\u8d77\u7684\u6557\u8840\u75c7\u3001\u6291\u5236\u76ae\u819a\u9ed1\u8272\u7d20\u816b\u7624\uff0c\u900f\u904e\u6291\u5236\u767c\u708e\u6a5f\u5236\u4e2d\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u5982<\/span>TNF- \u03b1<\/span>\u3001<\/span>IL-6<\/span>\u3001<\/span>COX-2<\/span>\u3001<\/span>IL-6<\/span>\u3001<\/span>COX-2<\/span>\u7b49\uff0c\u76ee\u524d\u4e5f\u6210\u529f\u5c07\u662d\u548c\u8349\u4ee5\u79d1\u5b78\u5316\u7684\u65b9\u5f0f\u65bc\u53f0\u4e2d\u8fb2\u696d\u6539\u826f\u5834\u5408\u4f5c\u9032\u884c\u7a2e\u690d\uff0c\u65b9\u4fbf\u672a\u4f86\u54c1\u8cea\u63a7\u5236\u8207\u7ba1\u7406\u3002<\/span><\/p>\n

\u53e6\u5916\u5730\u81bd\u8349\u4e2d\u7684\u500d\u534a\u841c\u5167\u916f\u985e (sesquiterpene lactone)\u4e4b\u500d\u534a\u841c\u6210\u5206<\/span>(deoxyelephantopin, DET)<\/span>\u53ef\u4ee5\u6291\u5236\u4e73\u764c\u764c\u7d30\u80de\u751f\u9577\u8207\u9077\u79fb\u7684\u4f5c\u7528\uff0c\u5177\u6709\u6297\u764c\u7684\u4f5c\u7528\uff0c\u4f46\u662f\u5c0d\u6b63\u5e38\u7d30\u80de\u4e0d\u5177\u6709\u50b7\u5bb3\u6027\uff0c\u76f8\u8f03\u50b3\u7d71\u7d2b\u6749\u9187\u985e\u85e5\u7269\u5c0d\u65bc\u6b63\u5e38\u7d30\u80de\u9020\u6210\u4e4b\u86cb\u767d\u8cea\u5177\u6709\u50b7\u5bb3\u6027\uff0c<\/span>DET<\/span>\u8f03\u70ba\u6eab\u548c\u4e14\u53ef\u4ee5\u5ef6\u9577\u4e73\u764c\u5c0f\u9f20\u7684\u58fd\u547d\u3002<\/span><\/p>\n

\u9e97\u82ac\u8001\u5e2b\u63d0\u5230\uff0c\u591a\u91cd\u85e5\u7406\u5b78<\/span>(polypharmacology)<\/span>\u7684\u89c0\u5ff5\u4f86\u770b\uff0c\u8349\u85e5\u7684\u6548\u679c\u4e0d\u50cf\u4e00\u822c\u6a19\u9776\u85e5\u7269\u53ea\u91dd\u5c0d\u764c\u7d30\u80de\u9032\u884c\u6cbb\u7642\uff0c\u53ef\u4ee5\u900f\u904e\u540c\u6642\u8abf\u63a7\u591a\u500b\u9776\u9ede\u52a0\u4ee5\u63a7\u5236\u3002\u5fae\u816b\u7624\u74b0\u5883\u5305\u62ec\u57fa\u8cea\u7d30\u80de\u3001\u8840\u7ba1\u589e\u751f\u3001\u8a0a\u606f\u50b3\u905e\u7b49\u4ee5\u652f\u6301\u8457\u816b\u7624\u7684\u751f\u9577\uff0c\u900f\u904e\u80de\u5916\u6ccc\u9ad4<\/span>(exosome)<\/span>\u5c07\u8a0a\u606f\u50b3\u905e\u51fa\u53bb\u4ee5\u5e6b\u52a9\u816b\u7624\u751f\u9577\uff0c\u900f\u904e<\/span>DET<\/span>\u53ef\u4ee5\u6709\u6548\u5730\u5c07<\/span>exosome<\/span>\u7684\u86cb\u767d\u8cea\u6210\u5206\u6539\u8b8a\uff0c\u4f7f\u816b\u7624\u8a0a\u606f\u7121\u6cd5\u50b3\u51fa\u53bb\u4e26\u6291\u5236\u816b\u7624\u7684\u751f\u9577\u3002<\/span><\/p>\n

\u76ee\u524d\u9e97\u82ac\u8001\u5e2b\u7814\u7a76\u5ba4\u5df2\u6210\u529f\u9a57\u8b49\u5177\u6f5b\u529b\u4e4b\u5316\u5b78\u9810\u9632\u6d3b\u6027\u690d\u7269\u6df7\u5408\u62bd\u51fa\u6210\u5206\u6216\u55ae\u4e00\u5316\u5408\u7269\uff0c\u5305\u62ec\uff1a\u91d1\u7dda\u9023\u62bd\u51fa\u7269\u3001\u662d\u548c\u8349\u534a\u4e73\u7cd6\u8102\u8cea\u3001\u5730\u81bd\u8349\u500d\u534a\u985e\u5316\u5408\u7269\u3001\u54b8\u8c50\u8349\u805a\u4e59\u7094\u985e\u4ee5\u53ca\u7d2b\u9310\u83ca<\/span>alkamides<\/span>\u7b49\uff0c\u671f\u671b\u672a\u4f86\u53ef\u4ee5\u5f9e\u53f0\u7063\u5728\u5730\u4e2d\u8349\u85e5\u4e2d\u767c\u6398\u51fa\u66f4\u591a\u5177\u6297\u764c\u3001\u9632\u764c\u7684\u6709\u6548\u5929\u7136\u6210\u5206\u5316\u5408\u7269\u3002<\/span>\u00a0<\/span><\/p>\n

\"\"<\/a>\"\"<\/a> \"\"<\/a>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u6587\/\u7167\u7247\uff1a\u6d2a\u9038\u5b89 \u5f9e\u96f6\u958b\u59cb\u7684\u8349\u85e5\u7814\u7a76\uff0c\u7d93\u904e20\u5e74\u7684\u5c08\u7cbe\u8983\u601d\uff0c […]<\/p>\n","protected":false},"author":1,"featured_media":9525,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-9523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9523"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9523\/revisions"}],"predecessor-version":[{"id":13030,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9523\/revisions\/13030"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/9525"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}