{"id":9355,"date":"2022-12-28T14:51:53","date_gmt":"2022-12-28T06:51:53","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=9355"},"modified":"2023-09-26T10:07:25","modified_gmt":"2023-09-26T02:07:25","slug":"%e6%85%88%e5%a4%a7%e7%94%9f%e7%a7%91%e7%b3%bb%e9%82%80%e4%ba%ac%e9%83%bd%e5%a4%a7%e5%ad%b8%e5%90%89%e6%9d%91%e6%88%90%e5%bc%98%e5%89%af%e6%95%99%e6%8e%88%e8%92%9e%e6%a0%a1%e8%ac%9b%e5%ad%b8%e5%8f%8a","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=9355","title":{"rendered":"\u6148\u5927\u751f\u79d1\u7cfb\u9080\u4eac\u90fd\u5927\u5b78\u5409\u6751\u6210\u5f18\u526f\u6559\u6388\u849e\u6821\u8b1b\u5b78\u53ca\u4ea4\u6d41"},"content":{"rendered":"<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\">\u6587<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u7167\u7247\uff1a\u751f\u547d\u79d1\u5b78\u7cfb<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u70ba\u62d3\u5c55\u5b78\u751f\u5c0d\u751f\u547d\u79d1\u5b78\u9818\u57df\u7684\u8996\u91ce\uff0c\u53ca\u589e\u9032\u5916\u8a9e\u79d1\u5b78\u807d\u8aaa\u7684\u80fd\u529b\uff0c\u7279\u5225\u9080\u8acb\u65e5\u672c\u4eac\u90fd\u5927\u5b78\u751f\u547d\u79d1\u5b78\u9662\u7684\u5409\u6751\u6210\u5f18\u526f\u6559\u6388\u849e\u6821\u8b1b\u5b78\u53ca\u4ea4\u6d41\u3002\u5409\u6751\u6559\u6388\u7684\u7814\u7a76\u9818\u57df\u6db5\u84cb\u751f\u7269\u7269\u7406\u3001\u751f\u91ab\u6750\u6599\u9818\u57df\uff0c\u5728\u9019\u6b21\u70ba\u671f<\/span><span class=\"s2\">4<\/span><span class=\"s1\">\u5929\u7684\u8b1b\u5b78\u4ea4\u6d41\u884c\u7a0b\u4e2d\uff0c\u5171\u5b89\u6392\u4e86<\/span><span class=\"s2\">1<\/span><span class=\"s1\">\u5834\u5c08\u984c\u6f14\u8b1b\u3001<\/span><span class=\"s2\">3<\/span><span class=\"s1\">\u5834\u78a9\u535a\u73ed\u8ab2\u7a0b\u52a9\u8b1b\u53ca<\/span><span class=\"s2\">1<\/span><span class=\"s1\">\u5834\u4ea4\u6d41\u5ea7\u8ac7\u6703\u3002<\/span><\/p>\n<p class=\"p3\" style=\"text-align: justify;\"><span class=\"s1\">\u5728<\/span><span class=\"s2\">12<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">6<\/span><span class=\"s1\">\u65e5\u7684\u5c08\u984c\u6f14\u8b1b\u4e2d\uff0c\u5409\u6751\u6559\u6388\u7684\u8b1b\u984c\u70ba\u300c<\/span><span class=\"s2\">How do post-translational modifications regulate liquid-liquid-phase separation during cell cycle?<\/span><span class=\"s1\">\u300d\u3002\u5409\u6751\u6559\u6388\u89e3\u8aaa\u86cb\u767d\u8cea\u78f7\u9178\u5316\u662f\u975e\u5e38\u91cd\u8981\u7684\u4e00\u500b\u8f49\u8b6f\u5f8c\u4fee\u98fe\u4f5c\u7528\uff0c\u5c0d\u65bc\u8abf\u63a7\u7d30\u80de\u9031\u671f\u3001\u7d30\u80de\u8a0a\u606f\u50b3\u905e\u4ee5\u53ca\u57fa\u56e0\u8868\u9054\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u4f46\u662f\u9019\u6a23\u7684\u4f5c\u7528\u5f88\u591a\u90fd\u767c\u751f\u5728\u88ab\u7a31\u70ba<\/span><span class=\"s2\">Intrinsically disordered region(IDR)<\/span><span class=\"s1\">\u9019\u7a2e\u975e\u4e09\u7d1a\u7d50\u69cb\u4e2d\u3002\u800c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e<\/span><span class=\"s2\">IDR<\/span><span class=\"s1\">\u6703\u5728\u7d30\u80de\u5167\u74b0\u5883\u7d93\u6b77<\/span><span class=\"s2\">liquid-liquid-phase(LLPS)<\/span><span class=\"s1\">\uff0c\u4ee5\u652f\u6490\u7d30\u80de\u819c\u5f62\u72c0\u4ee5\u53ca\u529f\u80fd\u6d3b\u6027\u3002\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u6307\u51fa\u78f7\u9178\u5316\u900f\u904e\u6539\u8b8a<\/span><span class=\"s2\">IDR<\/span><span class=\"s1\">\u7684\u5e36\u96fb\u6027\u800c\u5f71\u97ff<\/span><span class=\"s2\">LLPS<\/span><span class=\"s1\">\u5728\u7d30\u80de\u9031\u671f\u7684\u8abf\u63a7\u3002\u900f\u904e\u9019\u6a23\u7684\u6a5f\u5236\u539f\u7406\uff0c\u5409\u6751\u6559\u6388\u4ee5\u7d30\u80de\u9031\u671f\u4e2d\u5982\u4f55\u63a2\u6e2c\u6709\u7d72\u5206\u88c2\u662f\u5426\u6b63\u5e38\uff0c\u4ee5\u53ca\u7d30\u80de\u819c\u5728\u80de\u98f2\u4f5c\u7528\u7684\u52d5\u614b\u8b8a\u5316\u7b49\u7814\u7a76\u6210\u679c\u5411\u5927\u5bb6\u8aaa\u660e<\/span><span class=\"s2\">LLPS<\/span><span class=\"s1\">\u7684\u6a5f\u5236\u5982\u4f55\u88ab\u61c9\u7528\u65bc\u76f8\u95dc\u7684\u7814\u7a76\uff0c\u9032\u800c\u63a2\u8a0e\u5728\u7d30\u80de\u9031\u671f\u4e2d\u7684\u5404\u7a2e\u6a5f\u5236\u3002<\/span><\/p>\n<p class=\"p3\" style=\"text-align: justify;\"><span class=\"s2\">12<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">7<\/span><span class=\"s1\">\u65e5\u81f3<\/span><span class=\"s2\">12<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">9<\/span><span class=\"s1\">\u65e5\uff0c\u5409\u6751\u6559\u6388\u5206\u5225\u81f3\u86cb\u767d\u8cea\u5316\u5b78\u3001\u9ad8\u7b49\u751f\u7269\u5316\u5b78\u53ca\u539f\u5b50\u529b\u986f\u5fae\u93e1\u5b78\u7b49\u78a9\u535a\u58eb\u73ed\u8ab2\u7a0b\u5354\u540c\u6388\u8ab2\u3002\u53e6\u5916\uff0c\u4e5f\u8207\u6709\u8208\u8da3\u9032\u4e00\u6b65\u6df1\u8ac7\u7684\u5e2b\u751f\u9032\u884c\u4ea4\u6d41\u5ea7\u8ac7\u6703\uff0c\u6703\u4e2d\u5409\u6751\u6559\u6388\u63d0\u8d77\u4eac\u90fd\u5927\u5b78\u4ea4\u63db\u5b78\u7fd2\u8a08\u756b\uff0c\u5e0c\u671b\u53ef\u4ee5\u62db\u52df\u4f86\u81ea\u4e0d\u540c\u570b\u5bb6\u5c0d\u65bc\u751f\u547d\u79d1\u5b78\u7814\u7a76\u6709\u71b1\u5ff1\u7684\u540c\u5b78\u5011\u4e00\u540c\u4ea4\u6d41\u5b78\u7fd2\uff0c\u6b61\u8fce\u6709\u8208\u8da3\u53ca\u71b1\u5ff1\u7684\u540c\u5b78\u5011\u53ef\u4ee5\u7a4d\u6975\u7533\u8acb\u3002<\/span><\/p>\n<p class=\"p3\" style=\"text-align: justify;\"><span class=\"s1\">\u65bc\u5404\u9805\u6d3b\u52d5\u7d50\u675f\u5f8c\uff0c\u6709\u5b78\u751f\u8868\u793a<\/span><span class=\"s2\">:<\/span><span class=\"s1\">\u300c\u53c3\u8207\u5409\u6751\u6559\u6388\u7684\u6f14\u8b1b\u883b\u8003\u9a57\u82f1\u6587\u807d\u529b\uff0c\u4f46\u662f\u6559\u6388\u8aaa\u660e\u7684\u5167\u5bb9\u6211\u89ba\u5f97\u597d\u7406\u89e3\uff0c\u4e5f\u5c0d\u65bc\u751f\u79d1\u7814\u7a76\u7684\u9818\u57df\u62d3\u5c55\u66f4\u65b0\u7684\u8a8d\u8b58\u300d\uff1b\u53e6\u6709\u591a\u4f4d\u5b78\u751f\u8868\u793a\u5e0c\u671b\u672a\u4f86\u80fd\u7533\u8acb\u81f3\u4eac\u90fd\u5927\u5b78\u4ea4\u63db\u5b78\u7fd2\uff0c\u9664\u4e86\u589e\u5ee3\u898b\u805e\uff0c\u4ea6\u53ef\u7df4\u7fd2\u5916\u8a9e\u80fd\u529b\u3002\u611f\u8b1d\u5409\u6751\u6559\u6388\u5e36\u7d66\u6148\u5927\u5b78\u751f\u5b78\u7fd2\u4e0a\u7684\u6b63\u5411\u523a\u6fc0\uff0c\u5e0c\u671b\u672a\u4f86\u80fd\u5b9a\u671f\u9080\u8acb\u5409\u6751\u6559\u6388\u849e\u6821\u8b1b\u5b78\u4ea4\u6d41\u3002<\/span><\/p>\n<p><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9356 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/1-9-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9357 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/4-9-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9358 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/5-5-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9359 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/6-1-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9360 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/7-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9361 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/12\/unnamed-file-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\/\u7167\u7247\uff1a\u751f\u547d\u79d1\u5b78\u7cfb \u70ba\u62d3\u5c55\u5b78\u751f\u5c0d\u751f\u547d\u79d1\u5b78\u9818\u57df\u7684\u8996\u91ce\uff0c\u53ca\u589e\u9032 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9361,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-9355","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9355"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9355\/revisions"}],"predecessor-version":[{"id":12999,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9355\/revisions\/12999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/9361"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}