{"id":9181,"date":"2022-11-30T14:54:24","date_gmt":"2022-11-30T06:54:24","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=9181"},"modified":"2023-09-26T09:46:46","modified_gmt":"2023-09-26T01:46:46","slug":"%e6%85%88%e5%a4%a7%e6%95%99%e6%8e%88%e8%ac%9b%e7%b5%a6%e4%bd%a0%e8%81%bd-%e8%ab%be%e8%b2%9d%e7%88%be%e7%8d%8e%e5%be%97%e4%b8%bb%e4%b8%8d%e5%86%8d%e9%81%99%e4%b8%8d%e5%8f%af%e5%8f%8a","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=9181","title":{"rendered":"\u6148\u5927\u6559\u6388\u8b1b\u7d66\u4f60\u807d  \u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u4e0d\u518d\u9059\u4e0d\u53ef\u53ca"},"content":{"rendered":"<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\">\u6587<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u9662<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78<\/span><span class=\"s2\">28<\/span><span class=\"s1\">\u6b72\uff0c\u5f9e\u6c11\u570b<\/span><span class=\"s2\">83<\/span><span class=\"s1\">\u5e74\u5275\u7acb\u4e4b\u521d\u5373\u6df1\u8015\u5728\u5730\uff0c\u6148\u5927\u5e2b\u751f\u5011\u4e5f\u6301\u7e8c\u4ee5\u5c08\u696d\u670d\u52d9\u793e\u6703\u3002<\/span><span class=\"s2\">2022<\/span><span class=\"s1\">\u5e74\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u65bc<\/span><span class=\"s2\">10<\/span><span class=\"s1\">\u6708\u9678\u7e8c\u516c\u5e03\uff0c\u9019\u4e9b\u5f97\u4e3b\u53c8\u662f\u5982\u4f55\u6539\u8b8a\u4e16\u754c\uff1f\u70ba\u589e\u9032\u793e\u6703\u5927\u773e\u53ca\u6559\u8077\u54e1\u751f\u5c0d\u4ed6\u5011\u7372\u734e\u539f\u56e0\u6709\u66f4\u6df1\u5165\u7684\u77ad\u89e3\uff0c\u7279\u5225\u8209\u8fa6<\/span><span class=\"s2\">2022<\/span><span class=\"s1\">\u5e74\u8afe\u8c9d\u723e\u734e\u5c08\u984c\u79d1\u666e\u8b1b\u5ea7\uff0c\u9996\u5148\u767b\u5834\u7684\u5316\u5b78\u734e\u5c08\u984c\u6f14\u8b1b\uff0c\u9080\u8acb\u516c\u885b\u7cfb\u5c39\u7acb\u9298\u6559\u6388\u3001\u91ab\u5b78\u7cfb\u751f\u5316\u79d1\u5289\u54f2\u6587\u6559\u6388\u4e3b\u8b1b\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s2\">2022<\/span><span class=\"s1\">\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u65bc<\/span><span class=\"s2\">10<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">5<\/span><span class=\"s1\">\u65e5\u63ed\u66c9\uff0c\u4eca\u5e74\u7684\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u9812\u7d66\u4e09\u4f4d\u7814\u7a76\u5b78\u8005\uff1a\u590f\u666e\u840a\u65af<\/span><span class=\"s2\">(Barry Sharpless)<\/span><span class=\"s1\">\u3001\u6885\u723e\u9054\u723e<\/span><span class=\"s2\">(Morten Meldal)<\/span><span class=\"s1\">\u548c\u8c9d\u723e\u6258\u897f<\/span><span class=\"s2\">(Carolyn Bertozzi)<\/span><span class=\"s1\">\u3002\u524d\u5169\u4f4d\u5c07\u5316\u5b78\u5e36\u5165\u4e86\u529f\u80fd\u4e3b\u7fa9<\/span><span class=\"s2\">(functionalism)<\/span><span class=\"s1\">\u6642\u4ee3\uff0c\u4e26\u5960\u5b9a\u4e86\u9ede\u64ca\u5316\u5b78<\/span><span class=\"s2\">(click chemistry)<\/span><span class=\"s1\">\u7684\u57fa\u790e\uff1b\u5f8c\u8005\u5c07\u9ede\u64ca\u5316\u5b78\u63d0\u5347\u5230\u4e86\u4e00\u500b\u65b0\u7684\u7dad\u5ea6\uff0c\u4e26\u958b\u59cb\u4f7f\u7528\u5b83\u4f86\u63cf\u7e6a\u7d30\u80de\u3002\u900f\u904e\u61c9\u7528\u751f\u7269\u6b63\u4ea4\u5316\u5b78<\/span><span class=\"s2\">(biorthogonal chemistry)<\/span><span class=\"s1\">\u53cd\u61c9\uff0c\u53ef\u5354\u52a9\u767c\u5c55\u66f4\u6709\u91dd\u5c0d\u6027\u7684\u764c\u75c7\u6a19\u9776\u6cbb\u7642\uff0c\u4ee5\u53ca\u8a31\u591a\u5176\u5b83\u6aa2\u6e2c\u61c9\u7528\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u5f97\u734e\u7684\u8d77\u6e90\uff0c\u7531\u590f\u666e\u840a\u65af\u9996\u5148\u63d0\u51fa\u9ede\u64ca\u5316\u5b78\u7684\u6982\u5ff5\u958b\u59cb\uff0c\u4e5f\u5c31\u662f\u5206\u5b50\u69cb\u5efa\u7684\u5143\u4ef6\u53ef\u4ee5\u8fc5\u901f\u800c\u6709\u6548\u5730\u7d50\u5408\u5728\u4e00\u8d77\u3002\u4ed6\u548c\u6885\u723e\u9054\u723e\u4e0d\u7d04\u800c\u540c\u5730\u767c\u73fe\u4e86\u9019\u500b\u7372\u734e\u7684\u9ede\u64ca\u5316\u5b78\u53cd\u61c9\uff0c\u5c31\u662f\u4ee5\u4e9e\u9285\u96e2\u5b50\u50ac\u5316\u7684\u758a\u6c2e<\/span><span class=\"s2\">&#8211;<\/span><span class=\"s1\">\u7094\u70f4\u74b0\u5316\u52a0\u6210\u53cd\u61c9<\/span><span class=\"s2\">(azide-alkyne cycloaddition)<\/span><span class=\"s1\">\uff0c\u5f62\u6210\u74b0\u72c0\u7d50\u69cb\u7684\u4e09\u5511<\/span><span class=\"s2\">(triazole)<\/span><span class=\"s1\">\u5206\u5b50\u3002\u4e09\u5511\u985e\u5316\u5408\u7269\u5177\u6709\u7a69\u5b9a\u7684\u5316\u5b78\u7d50\u69cb\uff0c\u5b58\u5728\u65bc\u4e00\u4e9b\u85e5\u7269\u3001\u67d3\u6599\u548c\u8fb2\u696d\u5316\u5b78\u54c1\u7b49\u7b49\u7269\u8cea\u4e2d\u3002\u53ef\u9810\u898b\u7684\u662f\uff0c\u4eca\u5f8c\u5f88\u591a\u5206\u5b50\u7684\u5408\u6210\uff0c\u90fd\u53ef\u4ee5\u5c0f\u5206\u5b50\u5143\u4ef6\u70ba\u8d77\u9ede\uff0c\u5229\u7528\u9ede\u64ca\u5316\u5b78\u7684\u65b9\u5f0f\u4f86\u91cf\u7522\uff0c\u4ee5\u56e0\u61c9\u5404\u7a2e\u9818\u57df\u7684\u9700\u6c42\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u7136\u800c\uff0c\u64ca\u9ede\u5316\u5b78\u7206\u70b8\u6027\u7684\u61c9\u7528\u662f\u958b\u59cb\u53ef\u4f7f\u7528\u5728\u6d3b\u9ad4\u751f\u7269\u4e2d\u3002\u64ca\u9ede\u5316\u5b78\u6240\u4f7f\u7528\u7684\u758a\u6c2e\u8207\u7094\u70f4\uff0c\u5c31\u985e\u4f3c\u65bc\u4e00\u822c\u6211\u5011\u65e5\u5e38\u751f\u6d3b\u4f7f\u7528\u7684\u63d2\u6263\uff0c\u53ef\u4ee5\u5feb\u901f\u5730\u5c07\u5169\u500b\u4e0d\u540c\u7684\u5206\u5b50\u7a69\u5730\u9023\u7d50\u518d\u4e00\u8d77\u3002\u5728<\/span><span class=\"s2\">1990<\/span><span class=\"s1\">\u5e74\u4ee3\uff0c\u7576\u5927\u90e8\u5206\u7684\u751f\u7269\u5b78\u5bb6\u90fd\u81f4\u529b\u65bc\u751f\u7269\u5316\u5b78\u53ca\u5206\u5b50\u751f\u7269\u5b78\u7684\u7814\u7a76\uff0c\u8c9d\u723e\u6258\u897f\u537b\u4e3b\u8981\u7814\u7a76\u4e00\u985e\u5e7e\u4e4e\u6c92\u6709\u53d7\u5230\u4efb\u4f55\u95dc\u6ce8\u7684\u5206\u5b50\uff1a\u805a\u91a3\u985e\u3002\u7531\u65bc\u7f3a\u4e4f\u6709\u6548\u7684\u5de5\u5177\uff0c\u4f7f\u5f97\u7814\u7a76\u5de5\u4f5c\u9032\u5c55\u975e\u5e38\u7de9\u6162\uff0c\u63a5\u8457\u5979\u767c\u73fe\u53ef\u4ee5\u5229\u7528\u64ca\u9ede\u5316\u5b78\u7684\u65b9\u6cd5\u5c07\u87a2\u5149\u5206\u5b50\u9023\u7d50\u5230\u91a3\u985e\u4e0a\uff0c\u800c\u6210\u70ba\u6709\u6548\u5feb\u901f\u7684\u7814\u7a76\u5de5\u5177\u3002\u758a\u6c2e\u8207\u7094\u70f4\u57fa\u672c\u4e0a\u4e0d\u8207\u5df2\u77e5\u7684\u9ad4\u5167\u751f\u5316\u53cd\u61c9\u6709\u4ea4\u4e92\u4f5c\u7528\uff0c\u4e0d\u5e72\u64fe\u9ad4\u5167\u7684\u53cd\u61c9\u9014\u5f91\uff0c\u6240\u4ee5\u5177\u751f\u7269\u6b63\u4ea4\u7684<\/span><span class=\"s2\">(bioorthogonal)<\/span><span class=\"s1\">\u6027\u8cea\u3002\u7136\u800c\uff0c\u758a\u6c2e<\/span><span class=\"s2\">&#8211;<\/span><span class=\"s1\">\u7094\u70f4\u74b0\u5316\u52a0\u6210\u53cd\u61c9\u6240\u4f7f\u7528\u7684\u9285\u50ac\u5316\u5291\u537b\u5c0d\u751f\u7269\u9ad4\u6709\u6bd2\uff0c\u6240\u4ee5\u5979\u4f7f\u7528\u4e86\u4e00\u7a2e\u5f37\u8feb\u7094\u70f4\u5f62\u6210\u74b0\u72c0\u7684\u5316\u5b78\u7d50\u69cb\uff0c\u5176\u5f35\u529b\u8db3\u5920\u4f7f\u53cd\u61c9\u80fd\u5920\u9032\u884c\uff0c\u5982\u6b64\u5c31\u4e0d\u9700\u8981\u4f7f\u7528\u5230\u9285\u50ac\u5316\u5291\uff0c\u56e0\u800c\u9069\u5408\u65bc\u751f\u7269\u9ad4\u5167\u4f7f\u7528\u3002\u5982\u4eca\uff0c\u9019\u7a2e\u65b9\u6cd5\u5df2\u4e0d\u50c5\u9650\u65bc\u91a3\u985e\u8207\u542b\u91a3\u5206\u5b50\u7814\u7a76\uff0c\u5b83\u53ef\u4ee5\u6709\u6548\u5ee3\u6cdb\u5730\u4f7f\u7528\u5728\u7d30\u80de\u53ca\u751f\u7269\u9ad4\u5167\u91dd\u5c0d\u7279\u5b9a\u5206\u5b50\u7684\u87a2\u5149\u6a19\u8a18\u53ca\u8ffd\u8e64\u3001\u63a2\u8a0e\u751f\u7269\u5206\u5b50\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\u3001\u8ffd\u8e64\u9ad4\u5167\u764c\u7d30\u80de\u5206\u5e03\u3001\u5c08\u4e00\u6027\u9023\u7d50\u85e5\u7269\u5206\u5b50\u8207\u76ee\u6a19\u8b8a\u7570\u7d30\u80de\u53ca\u764c\u7d30\u80de\uff0c\u4ee5\u53ca\u751f\u7269\u6aa2\u6e2c\u6676\u7247\u88fd\u4f5c\u7b49\u3002\u76f8\u4fe1\u5728\u672a\u4f86\uff0c\u6703\u6709\u66f4\u591a\u7684\u751f\u7269\u6b63\u4ea4\u5316\u5b78\u7684\u61c9\u7528\u88ab\u958b\u767c\u51fa\u4f86\uff0c\u5c0d\u4eba\u985e\u5065\u5eb7\u8207\u798f\u7949\u63d0\u4f9b\u6975\u5927\u7684\u52a9\u76ca\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u5c39\u7acb\u9298\u6559\u6388\u53ca\u751f\u5316\u79d1\u5289\u54f2\u6587\u6559\u6388\u5728\u4e00\u5c0f\u6642\u7684\u7c21\u77ed\u6f14\u8b1b\u4e2d\uff0c\u6df1\u5165\u6dfa\u51fa\u5730\u5f15\u9818\u5927\u773e\u53ca\u6559\u8077\u54e1\u751f\u7aba\u63a2\u900f\u904e\u5c07\u5206\u5b50\u7d50\u69cb\u7c21\u55ae\u6709\u6548\u62fc\u63a5\uff0c\u5982\u540c\u6ed1\u9f20\u9ede\u64ca\u4fbf\u80fd\u5b8c\u6210\u4e00\u500b\u6307\u4ee4\uff0c\u8fc5\u901f\u53ef\u9760\u5730\u5b8c\u6210\u5404\u5f0f\u5f62\u5f62\u8272\u8272\u5206\u5b50\u7684\u5316\u5b78\u5408\u6210\uff0c\u4e0d\u6703\u7834\u58de\u751f\u7269\u9ad4\u5167\u7d30\u80de\u7684\u6b63\u5e38\u5316\u5b78\u53cd\u61c9\uff0c\u7522\u751f\u7684\u526f\u7522\u7269\u4e5f\u5c11\u3002\u4e09\u4f4d\u5b78\u8005\u767c\u5c55\u51fa\u4f86\u7684\u6280\u8853\uff0c\u5982\u4eca\u88ab\u5ee3\u6cdb\u904b\u7528\u5728\u89c0\u5bdf\u7d30\u80de\u751f\u7406\u53cd\u61c9\u904e\u7a0b\uff0c\u751f\u7269\u6b63\u4ea4\u5316\u5b78\u4e5f\u6709\u52a9\u764c\u75c7\u6a19\u9776\u6cbb\u7642\u3001\u91a3\u985e\u75ab\u82d7\u958b\u767c\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6f14\u8b1b\u5c3e\u8072\uff0c\u91ab\u5b78\u9662\u8b1d\u5764\u53e1\u526f\u9662\u9577\u611f\u6069\u6709\u6b64\u6a5f\u6703\u8b93\u5927\u5bb6\u53ef\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u4e00\u8d77\u4ea4\u6d41\u5206\u4eab\uff0c\u66f4\u611f\u8b1d\u5169\u4f4d\u6559\u6388\u4fc3\u9032\u5c08\u696d\u8207\u975e\u5c08\u696d\u4ee5\u53ca\u4e0d\u540c\u5c08\u696d\u9593\u7684\u6e9d\u901a\u4e86\u89e3\uff0c\u5e0c\u671b\u900f\u904e\u5c08\u5bb6\u5b78\u8005\u7684\u4ecb\u7d39\uff0c\u8b93\u793e\u6703\u5927\u773e\u53ca\u6559\u8077\u54e1\u751f\u80fd\u4e86\u89e3\u570b\u969b\u9802\u5c16\u5b78\u8853\u7814\u7a76\u53ca\u5176\u5c0d\u793e\u6703\u767c\u5c55\u7684\u8ca2\u737b\uff0c\u4e26\u80af\u5b9a\u79d1\u5b78\u7814\u7a76\u3001\u79d1\u5b78\u65b9\u6cd5\u3001\u79d1\u5b78\u7cbe\u795e\u7684\u50f9\u503c\u8207\u91cd\u8981\u6027\uff0c<\/span><span class=\"s2\">18<\/span><span class=\"s1\">\u65e5\u9084\u6709\u91ab\u5b78\u734e\u7684\u5206\u4eab\uff0c\u6b61\u8fce\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u3002<\/span><\/p>\n<p><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9182 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524.jpg\" alt=\"\" width=\"1025\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524.jpg 1025w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524-730x486.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8524-272x182.jpg 272w\" sizes=\"auto, (max-width: 1025px) 100vw, 1025px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9183 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/MG_8532-2-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a 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