{"id":9118,"date":"2022-11-30T14:37:59","date_gmt":"2022-11-30T06:37:59","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=9118"},"modified":"2023-09-26T09:23:36","modified_gmt":"2023-09-26T01:23:36","slug":"%e6%85%88%e5%a4%a7%e9%86%ab%e7%a7%91%e5%8d%9a%e9%82%80%e8%ab%8b%e4%b8%ad%e7%a0%94%e9%99%a2%e9%99%b3%e5%bf%97%e6%88%90%e7%a0%94%e7%a9%b6%e5%93%a1%e5%88%86%e4%ba%ab-sensing-acidosis-nociceptio","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=9118","title":{"rendered":"\u6148\u5927\u91ab\u79d1\u535a\u9080\u8acb\u4e2d\u7814\u9662\u9673\u5fd7\u6210\u7814\u7a76\u54e1\u5206\u4eab\u201c Sensing Acidosis: Nociception or Sngception?\u201d"},"content":{"rendered":"<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\">\u6587<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u5716\uff1a\u91ab\u79d1\u6240<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s2\">2021<\/span><span class=\"s1\">\u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u5f97\u734e\u4eba\u6731\u91cc\u96c5\u65af<\/span><span class=\"s2\">(David Julius)<\/span><span class=\"s1\">\u5c0d\u65bc\u71b1\u8207\u75db\u7684\u611f\u89ba\u4f86\u6e90\u662f\u7531\u8fa3\u6912\u7d20\u53d7\u9ad4\u6240\u81f4\u3002\u5176\u4e2d\u6a5f\u68b0\u529b\u53d7\u9ad4\u8207\u75db\u89ba\u4e4b\u9593\u7684\u95dc\u806f\u5bc6\u4e0d\u53ef\u5206\uff0c\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u535a\u58eb\u73ed\u9080\u8acb\u4e2d\u592e\u7814\u7a76\u9662\u9673\u5fd7\u6210\u535a\u58eb\u5206\u4eab\u201c<\/span> <span class=\"s2\">Sensing Acidosis: Nociception or Sngception?\u201d<\/span><span class=\"s1\">\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u9673\u5fd7\u6210\u535a\u58eb\u73fe\u8077\u65bc\u4e2d\u7814\u9662\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240\u7814\u7a76\u54e1\u517c\u526f\u6240\u9577\uff0c\u81f4\u529b\u65bc\u7814\u7a76\u75e0\u75db\u89ba\u4e2d\u7684\u8a0a\u606f\u50b3\u905e\u8def\u5f91\u8207\u57fa\u56e0\u7684\u76f8\u95dc\u6027\uff0c\u81f3\u4eca\u5df2\u767c\u8868\u4e86<\/span><span class=\"s2\">53<\/span><span class=\"s1\">\u7bc7\u76f8\u95dc\u6587\u7ae0\u65bc\u570b\u969b\u5b78\u8853\u671f\u520a\uff0c\u5176\u7814\u7a76\u5305\u542b\u4e86\u4e09\u5927\u65b9\u5411\uff0c\u5206\u5225\u662f<\/span><span class=\"s2\">: <\/span><span class=\"s1\">\u63a2\u8a0e\u5f15\u8d77\u6162\u6027\u808c\u8089\u75e0\u75db\u7684\u5206\u5b50\u6a5f\u5236\u3001\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u5728\u795e\u7d93\u50b3\u5c0e\u8207\u751f\u7406\u6046\u5b9a\u6240\u626e\u6f14\u7684\u89d2\u8272\u8207\u9078\u6b96\u6a5f\u68b0\u529b\u53d7\u9ad4\u7684\u57fa\u56e0\u4e26\u63a2\u8a0e\u5176\u5728\u6162\u6027\u9178\u75db\u6240\u626e\u6f14\u7684\u89d2\u8272\u3002\u5c0d\u65bc\u75db\u8207\u9178\u7684\u611f\u89ba\u4f86\u6e90\uff0c\u4ed6\u4e3b\u5f35\u5169\u8005<\/span><span class=\"s2\">(<\/span><span class=\"s1\">\u9178\u89ba\u8207\u75db\u89ba<\/span><span class=\"s2\">)<\/span><span class=\"s1\">\u662f\u4f86\u81ea\u4e0d\u540c\u7684\u611f\u89ba\uff0c\u6709\u8da3\u7684\u662f\uff0c\u9178\u662f\u9020\u6210\u75bc\u75db\u7684\u4e3b\u56e0\u4e4b\u4e00\uff0c\u7d44\u7e54\u9178\u5316\u8207\u767c\u708e\u3001\u7f3a\u8840\u7b49\u5f15\u8d77\u7684\u6162\u6027\u75bc\u75db\u5177\u6709\u9ad8\u5ea6\u7684\u76f8\u95dc\u6027\uff0c\u7814\u7a76\u9178\u8a0a\u606f\u7684\u50b3\u905e\u6a5f\u5236\u8207\u8def\u5f91\u8207\u57fa\u56e0\u9593\u76f8\u4e92\u4f5c\u7528\u6709\u52a9\u65bc\u5c0d\u65bc\u6b62\u75db\u76f8\u95dc\u6cbb\u7642\u63d0\u4f9b\u8fd1\u4e00\u6b65\u7684\u5c0d\u7b56\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u9996\u5148\u75db\u611f\u7684\u795e\u7d93\u6709\u4e09\u7a2e\u65b9\u5f0f\u53ef\u4ee5\u523a\u6fc0\u901a\u9053\u6d3b\u5316\uff0c\u5206\u5225\u662f\u8fa3\u6912\u7d20\u53d7\u9ad4\u3001\u71b1\u75db\u611f\u8207\u9178\u611f\uff0c\u5176\u4e2d\u8fa3\u6912\u7d20\u53d7\u9ad4<\/span><span class=\"s2\">1(TRPV1)<\/span><span class=\"s1\">\u6703\u53d7\u5230\u9ad8\u6eab\u6d3b\u5316\uff0c\u53e6\u5916\u767c\u662f\u5728\u4f4e\u6eab\u6642\u6703\u6fc0\u767c<\/span><span class=\"s2\">TRPM8<\/span><span class=\"s1\">\u53d7\u9ad4\uff0c\u4e0a\u8ff0\u7814\u7a76\u767c\u73fe\u53d7\u9ad4\u6703\u56e0\u6eab\u5ea6\u7684\u8b8a\u5316\u800c\u7522\u751f\u4e0d\u540c\u7684\u8a0a\u606f\u3002\u611f\u77e5\u7d44\u7e54\u9178\u4e2d\u6bd2\u662f\u9ad4\u611f\u795e\u7d93\u7cfb\u7d71\u5c0d\u6709\u5bb3\u523a\u6fc0\u4f5c\u51fa\u53cd\u61c9\u7684\u91cd\u8981\u529f\u80fd\u3002\u5728\u75bc\u75db\u8a3a\u65b7\u4e2d\uff0c\u9178\u75db\u611f\u662f\u5404\u7a2e\u6025\u6027\u548c\u6162\u6027\u75bc\u75db\u7d9c\u5408\u5fb5\u7684\u7279\u5fb5\u6027\u611f\u89ba\u8868\u578b\uff0c\u4f8b\u5982\u5ef6\u9072\u6027\u808c\u8089\u9178\u75db\u3001\u808c\u7b4b\u819c\u75db\u3001\u7e96\u7dad\u808c\u75db\u3001\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u3001\u8170\u690e\u795e\u7d93\u6839\u75c5\u7b49\u3002\u7136\u800c\uff0c\u96d6\u7136\u9178\u75db\u5728\u82f1\u8a9e\u4e2d\u610f\u5473\u8457\u75bc\u75db\uff0c\u4f46\u5c0d\u65bc\u8a31\u591a\u5f62\u5f0f\u7684\u7269\u7406\u6cbb\u7642\uff0c\u5982\u91dd\u7078\u3001\u589e\u751f\u7642\u6cd5\u3001\u6cbb\u7642\u6027\u8d85\u8072\u548c\u7121\u6c27\u9ede\u7642\u6cd5\uff0c\u9178\u75db\u611f\u4e5f\u662f\u6210\u529f\u93ae\u75db\u7684\u6a19\u8a8c\u3002\u9019\u4e00\u9ede\uff0c\u9178\u6216\u9178\u75db\u7684\u611f\u89ba\u4e26\u4e0d\u7e3d\u662f\u50b7\u5bb3\u6027\u7684\uff08\u6216\u75db\u82e6\u7684\uff09\uff0c\u4e26\u4e14\u53ef\u80fd\u5177\u6709\u6297\u50b7\u5bb3\u6027\u3002\u6b64\u5916\uff0c\u8a31\u591a\u975e\u50b7\u5bb3\u6027\u9ad4\u611f\u795e\u7d93\u5143\u5c0d\u9178\u654f\u611f\u3002\u7279\u5225\u662f\u9178\u611f\u61c9\u96e2\u5b50\u901a\u9053<\/span><span class=\"s2\"> (ASICs) <\/span><span class=\"s1\">\u5728\u672c\u9ad4\u611f\u53d7\u5668\u4e2d\u9ad8\u5ea6\u8868\u9054\u4e26\u53c3\u8207\u7cfb\u93c8\u6a21\u5f0f\u6a5f\u68b0\u8f49\u5c0e\u3002\u70ba\u4e86\u4fc3\u9032\u5c0d\u9178\u75db\u611f\u89ba\u7684\u5206\u5b50\u548c\u795e\u7d93\u751f\u7269\u5b78\u6a5f\u5236\u7684\u7814\u7a76\uff0c\u6211\u5011\u63d0\u51fa\u4e86\u4e00\u500b\u65b0\u6982\u5ff5<\/span><span class=\"s2\"> sngception (sng-ception) <\/span><span class=\"s1\">\u4f86\u63cf\u8ff0\u9ad4\u611f\u795e\u7d93\u7cfb\u7d71\u5c0d\u611f\u77e5\u7d44\u7e54\u9178\u4e2d\u6bd2\u7684\u53cd\u61c9\u4e26\u5c07\u5176\u8207\u50b7\u5bb3\u611f\u53d7\u5340\u5206\u958b\u4f86\u3002<\/span><span class=\"s2\"> Sng<\/span><span class=\"s1\">\uff08\u767c\u97f3\u70ba<\/span><span class=\"s2\"> s\u0259\u014b<\/span><span class=\"s1\">\uff0c\u9178\uff09\u662f\u4e00\u500b\u53f0\u7063\u8a5e\uff0c\u4ee3\u8868\u611f\u89ba\u9178\u75db\u7684\u72c0\u614b\uff0c\u53ef\u80fd\u985e\u4f3c\u65bc\u6cd5\u8a9e\u4e2d\u7684<\/span><span class=\"s2\">\u201ccourbature\u201d<\/span><span class=\"s1\">\u6216\u5fb7\u570b\u7684<\/span><span class=\"s2\">\u201cmuskelkater\u201d<\/span><span class=\"s1\">\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s2\">Sngception <\/span><span class=\"s1\">\u53ef\u80fd\u8207\u50b7\u5bb3\u611f\u53d7\u90e8\u5206\u91cd\u758a\uff0c\u4f46\u5b83\u4e5f\u50b3\u905e\u6297\u50b7\u5bb3\u611f\u53d7\u3001\u672c\u9ad4\u611f\u53d7\u548c\u7619\u7662\u611f\u53d7\u3002\u96d6\u7136\u8cea\u5b50\u611f\u61c9\u96e2\u5b50\u901a\u9053\u548c<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u6216\u6709\u52a9\u65bc<\/span><span class=\"s2\"> sngception <\/span><span class=\"s1\">\u7684\u53d7\u9ad4\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u5019\u9078\u819c\u86cb\u767d\u5305\u62ec<\/span><span class=\"s2\"> ASIC <\/span><span class=\"s1\">\u6210\u54e1\u3001\u77ac\u6642\u53d7\u9ad4\u96fb\u4f4d<\/span><span class=\"s2\"> (TRP) <\/span><span class=\"s1\">\u901a\u9053\u3001\u8cea\u5b50\u611f\u61c9<\/span><span class=\"s2\"> G <\/span><span class=\"s1\">\u86cb\u767d\u5076\u806f\u53d7\u9ad4\u548c\u5169\u5b54\u9240<\/span><span class=\"s2\"> (K<\/span><span class=\"s4\"><sub>2<\/sub><\/span><span class=\"s2\">P)<\/span><span class=\"s1\">\u6e20\u9053\u3002\u56e0\u6b64\uff0c\u8b1b\u8005\u8a2d\u8a08\u4e86\u4e00\u7cfb\u5217\u57fa\u56e0\u64cd\u4f5c\u4f86\u63a2\u7d22\u53ef\u80fd\u53c3\u8207\u5c0f\u9f20\u6a21\u578b\u4e2d<\/span><span class=\"s2\"> sngception <\/span><span class=\"s1\">\u7684\u8cea\u5b50\u611f\u61c9\u5206\u5b50\u548c<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u6216\u795e\u7d93\u5143\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6b64\u5916\uff0c\u5f9e\u81e8\u5e8a\u65b9\u9762\uff0c\u4e5f\u8b49\u660e<\/span><span class=\"s2\"> sng<\/span><span class=\"s1\">\uff08\u9178\u75db\uff09\u548c\u75bc\u75db\u662f\u5169\u7a2e\u53ef\u5340\u5206\u7684\u75c7\u72c0\uff0c\u5c0d\u6162\u6027\u4f4e\u8840\u58d3\u60a3\u8005\u7684\u81e8\u5e8a\u5f71\u97ff\u4e0d\u540c\u3002\u80cc\u75db\u548c\u7e96\u7dad\u808c\u75db\u3002\u7e3d\u4e4b\uff0c\u4e86\u89e3\u60a3\u8005\u7684<\/span><span class=\"s2\"> sng <\/span><span class=\"s1\">\u5c07\u70ba\u6162\u6027<\/span><span class=\"s2\">\u201csng-pain\u201d<\/span><span class=\"s1\">\u7684\u6709\u6548\u6cbb\u7642\u63d0\u4f9b\u65b0\u7684\u898b\u89e3\u3002<\/span><\/p>\n<p><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9119 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/1-24-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9120 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3.png\" alt=\"\" width=\"1024\" height=\"1479\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3.png 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3-208x300.png 208w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3-709x1024.png 709w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3-768x1109.png 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3-730x1054.png 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2022\/11\/2-3-435x628.png 435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\/\u5716\uff1a\u91ab\u79d1\u6240 2021\u5e74\u8afe\u8c9d\u723e\u751f\u91ab\u5f97\u734e\u4eba\u6731\u91cc\u96c5\u65af(Davi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-9118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9118"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9118\/revisions"}],"predecessor-version":[{"id":12955,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/9118\/revisions\/12955"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/9119"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}