{"id":8549,"date":"2022-08-23T11:18:19","date_gmt":"2022-08-23T03:18:19","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=8549"},"modified":"2023-09-25T16:19:34","modified_gmt":"2023-09-25T08:19:34","slug":"%e6%85%88%e5%a4%a7%e7%a0%94%e7%a9%b6%e7%99%bc%e7%8f%be-%e9%a0%90%e9%98%b2%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%e8%a8%98%e6%86%b6%e9%80%80%e5%a4%b1%e7%9a%84%e6%96%b0%e5%b8%8c%e6%9c%9b","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=8549","title":{"rendered":"\u6148\u5927\u7814\u7a76\u767c\u73fe \u9810\u9632\u963f\u8332\u6d77\u9ed8\u75c7\u8a18\u61b6\u9000\u5931\u7684\u65b0\u5e0c\u671b"},"content":{"rendered":"

\u6148\u5927\u7814\u7a76\u767c\u73fe \u9810\u9632\u963f\u8332\u6d77\u9ed8\u75c7\u8a18\u61b6\u9000\u5931\u7684\u65b0\u5e0c\u671b<\/p>\n

\u64b0\u6587\uff0f\u8449\u7da0\u8212\uff1b\u651d\u5f71\uff0f\u66fe\u7e7c\u92d2<\/span><\/p>\n

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M01\u662f\u4eba\u5de5\u5408\u6210\u7684\u5316\u5408\u7269\uff0c\u5289\u6821\u9577\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u4f7f\u7528\u4e86M01\u7684\u963f\u8332\u6d77\u9ed8\u5c0f\u9f20\uff0c\u5176\u77ed\u671f\u5de5\u4f5c\u8a18\u61b6\u53ca\u65b9\u5411\u8a18\u61b6\u6062\u5fa9\u4e86\uff0c\u9019\u53ef\u7531\u5982T\u578b\u8ff7\u5bae\u53ca\u6c34\u8ff7\u5bae\u7684\u53cd\u5411\u5b78\u7fd2\u7b49\u6e2c\u8a66\u8b49\u5be6\u3002\u670d\u7528 M01\u5f8c\uff0c\u5c0f\u9f20\u5927\u8166\u6d77\u99ac\u8ff4\u4e2d\u8207\u81ea\u566c\u4f5c\u7528\u76f8\u95dc\u7684\u5206\u5b50\u8868\u9054\u589e\u52a0\uff0c\u800c\u767c\u708e\u9ad4\u76f8\u95dc\u86cb\u767d\u8cea\uff08\u5982NLRP3\uff09\u7684\u8868\u9054\u91cf\u5247\u6e1b\u5c11\u3002\u9032\u4e00\u6b65\u6e2c\u8a66\u5f8c\u767c\u73fe\uff0cM01\u53ef\u80fd\u662f\u7d93\u7531\u8abf\u7bc0\u53ef\u964d\u89e3\u86cb\u767d\u8cea\u7684\u6cdb\u86cb\u767d\u5316(ubiqutination)\u904e\u7a0b\u4e2d\u7684\u91cd\u8981\u5206\u5b50E3\u9023\u63a5\u9176(E3 ligase)\uff0c\u4f7f\u81ea\u566c\u4f5c\u7528\u4e0a\u5347\u3001\u767c\u708e\u53cd\u61c9\u4e0b\u964d\uff0c\u7576\u81ea\u566c\u4f5c\u7528\u8207\u767c\u708e\u53cd\u61c9\u9054\u5230\u5065\u5eb7\u7684\u5e73\u8861\u5f8c\uff0c\u5373\u53ef\u53cd\u8f49\u963f\u8332\u6d77\u9ed8\u75c7\u9020\u6210\u7684\u5de5\u4f5c\u53ca\u65b9\u5411\u8a18\u61b6\u7f3a\u640d\u3002<\/span><\/p>\n

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HECT-E3\u9023\u63a5\u9176\u662f\u300cE3\u9023\u63a5\u9176\u300d\u5bb6\u65cf\u7684\u6210\u54e1\u4e4b\u4e00\uff0c\u5b83\u5011\u7684\u529f\u80fd\u5c31\u662f\u5c07\u4e0d\u9700\u8981\u6216\u4e0d\u6b63\u5e38\u6298\u758a\u7684\u86cb\u767d\u8cea\u63a5\u4e0a\u6cdb\u7d20\uff08ubiquitin\uff09\u3002\u63a5\u4e0a\u6cdb\u7d20\u4ee5\u5f8c\u7684\u86cb\u767d\u8cea\uff0c\u5c31\u6703\u88ab\u6cdb\u86cb\u767d\u5316\u7684\u904e\u7a0b\u5206\u89e3\u6389\u3002\u76ee\u524d\u5df2\u77e5\u7684E3\u9023\u63a5\u9176\u6709\u4e94\u767e\u5230\u4e00\u5343\u500b\uff0c\u5b83\u5011\u5c31\u50cf\u7d30\u80de\u4e2d\u7684\u74b0\u4fdd\u83e9\u85a9\uff0c\u8ca0\u8cac\u628a\u4e0d\u9700\u8981\u7684\u6771\u897f\u52a0\u4e0a\u6a19\u7c64\u4ee5\u9032\u884c\u5206\u89e3\u3002HECT-E3\u9023\u63a5\u9176\u8ca0\u8cac\u8655\u7406\u555f\u52d5\u81ea\u566c\u4f5c\u7528\u7684\u86cb\u767d\u50cf\u662fBeclin-1\uff0c\u7576\u81ea\u566c\u4f5c\u7528\u529f\u80fd\u4f4e\u4e0b\u6642\uff0c\u82e5\u80fd\u8abf\u7bc0HECT-E3\u9023\u63a5\u9176\uff0c\u4f7f\u5b83\u7684\u5de5\u4f5c\u6548\u7387\u7a0d\u964d\uff0c\u4ee5\u63d0\u5347\u81ea\u566c\u4f5c\u7528\uff0c\u5c31\u53ef\u7dad\u6301\u5927\u8166\u5167\u5c0d\u65bc\u4e0d\u6b63\u5e38\u86cb\u767d\u8cea\u7684\u6e05\u6d88\u3002<\/span><\/p>\n

\u5289\u6021\u5747\u6821\u9577\u7684\u7814\u7a76\u5718\u968a\u5c07\u6703\u7e7c\u7e8c\u7814\u7a76M01\u7684\u4f5c\u7528\u6a5f\u8f49\uff0c\u900f\u904e\u8207\u751f\u79d1\u7cfb\u4e3b\u4efb\u8a31\u8c6a\u4ec1\u6559\u6388\u7684\u5408\u4f5c\uff0c\u4ee5\u5206\u5b50\u6a21\u64ec\u7684\u65b9\u5f0f\u627e\u51fa\u9664\u4e86HECT-E3\u9023\u63a5\u9176\u4ee5\u5916\uff0c\u662f\u5426\u6709\u5176\u4ed6\u7684E3\u9023\u63a5\u9176\u8207M01\u6709\u4e92\u52d5\uff0c\u9078\u64c7\u51fa\u6709\u6f5b\u529b\u7684\u85e5\u7269\u5019\u9078\u5206\u5b50\u3002\u53e6\u5916\uff0c\u5289\u6821\u9577\u7684\u7814\u7a76\u5718\u968a\u4e5f\u6295\u5165\u7814\u767c\u5176\u4ed6\u80fd\u53cd\u8f49\u963f\u8332\u6d77\u9ed8\u75c7\u8a18\u61b6\u9000\u5316\u7684\u8349\u85e5\u5316\u5408\u7269\uff0c\u5e0c\u671b\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u80fd\u6709\u6548\u5730\u9810\u9632\u3001\u6cbb\u7642\u963f\u8332\u6d77\u9ed8\u75c7\u5f15\u767c\u7684\u8a18\u61b6\u9000\u5316\u3002<\/span><\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n

Pavithra Suresh et. al., 2022. Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice. Frontiers in Aging Neuroscience. doi: 10.3389\/fnagi.2022.916904<\/span><\/p>\n

\"\"<\/a> \"\"<\/a> \"\"<\/a> \"\"<\/a> \"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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