{"id":6920,"date":"2021-08-25T08:59:01","date_gmt":"2021-08-25T00:59:01","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=6920"},"modified":"2023-09-25T08:52:04","modified_gmt":"2023-09-25T00:52:04","slug":"%e6%85%88%e5%a4%a7%e5%bd%ad%e5%a3%ab%e5%a5%95%e8%80%81%e5%b8%ab%e6%8a%95%e5%85%a5%e5%af%84%e7%94%9f%e8%9f%b2%e7%96%ab%e8%8b%97%e4%bd%90%e5%8a%91%e9%96%8b%e7%99%bc","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=6920","title":{"rendered":"\u6148\u5927\u5f6d\u58eb\u5955\u8001\u5e2b\u6295\u5165\u5bc4\u751f\u87f2\u75ab\u82d7\u4f50\u5291\u958b\u767c"},"content":{"rendered":"<p style=\"text-align: justify;\">\u6587\uff0f\u7167\u7247\uff1a\u8449\u7da0\u8212<\/p>\n<p style=\"text-align: justify;\">\u96a8\u84572019\u51a0\u72c0\u75c5\u6bd2\u75c5\u7684alpha\u8b8a\u7570\u682a\uff08\u4fd7\u7a31\u7684\u82f1\u570b\u8b8a\u7570\u682a\uff09\u5728\u4e94\u6708\u5165\u4fb5\u53f0\u7063\uff0c\u6253\u75ab\u82d7\u5df2\u7d93\u6210\u70ba\u5168\u6c11\u904b\u52d5\u3002\u6700\u8fd1\u65b0\u52a0\u5165\u75ab\u82d7\u9663\u71df\u7684\u9ad8\u7aef\u75ab\u82d7\uff0c\u66f4\u8b93\u75ab\u82d7\u6210\u70ba\u5168\u6c11\u71b1\u8b70\u7684\u9805\u76ee\u3002\u4f46\u4e0d\u77e5\u9053\u5927\u5bb6\u807d\u904e\u300c\u4f50\u5291\u300d\u55ce\uff1f<\/p>\n<p style=\"text-align: justify;\">\u4f50\u5291\uff08adjuvant\uff09\u662f\u7528\u4f86\u5e6b\u52a9\u6211\u5011\u7684\u8eab\u9ad4\u5c0d\u76ee\u6a19\u6297\u539f\u8a98\u767c\u3001\u589e\u5f37\u6216\u5ef6\u9577\u514d\u75ab\u53cd\u61c9\u7684\u7269\u8cea\u3002\u4e00\u822c\u4f86\u8aaa\uff0c\u5982\u679c\u662f\u50b3\u7d71\u7684\u6e1b\u6bd2\u75ab\u82d7\uff0c\u56e0\u70ba\u5df2\u7d93\u5177\u6709\u985e\u4f3c\u4f50\u5291\u7684\u6210\u5206\u5728\u88e1\u9762\uff0c\u4e26\u4e0d\u9700\u8981\u4f50\u5291\u7684\u52a0\u5165\uff1b\u4f46\u5982\u9ad8\u7aef\u75ab\u82d7\u9019\u7a2e\u86cb\u767d\u8cea\u6b21\u55ae\u5143\u75ab\u82d7\uff0c\u5c31\u9700\u8981\u6709\u4f50\u5291\u7684\u5e6b\u52a9\u4e86\u3002<\/p>\n<p style=\"text-align: justify;\">\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u7269\u5316\u5b78\u78a9\u58eb\u73ed\u7684\u5f6d\u58eb\u5955\u8001\u5e2b\uff0c\u4ed6\u7684\u7814\u7a76\u4e3b\u8981\u662f\u91dd\u5c0d\u66fc\u68ee\u8840\u5438\u87f2\uff08<em>Schistosoma mansoni<\/em>\uff09\u3002\u8840\u5438\u87f2\u75c5\u5c6c\u65bcWHO\u6240\u5ba3\u5e03\u7684\u516d\u5927\u71b1\u5e36\u91ab\u5b78\u75be\u75c5\u4e4b\u4e00\uff0c\u6bcf\u5e74\u53d7\u611f\u67d3\u7684\u4eba\u6578\u8d85\u904e\u5169\u5104\u4eba\uff0c\u4e3b\u8981\u5728\u4e9e\u6d32\u3001\u975e\u6d32\u3001\u4e2d\u5357\u7f8e\u6d32\u5730\u5340\u3002\u66fc\u68ee\u8840\u5438\u87f2\u611f\u67d3\u6703\u5f15\u767c\u4eba\u9ad4\u809d\u7e96\u7dad\u5316\u751a\u81f3\u809d\u786c\u5316\uff08\u87f2\u5375\u5806\u7a4d\u65bc\u809d\u81df\u5f15\u767c\uff09\uff0c\u81e8\u5e8a\u4e0a\u96d6\u7136\u5df2\u6709\u85e5\u7269&#8211;\u5421\u55b9\u916e\uff08Praziquantel\uff09\u53ef\u6cbb\u7642\uff0c\u4f46\u76ee\u524d\u5df2\u958b\u59cb\u51fa\u73fe\u6297\u85e5\u6027\u3002\u800c\u4e14\uff0c\u611f\u67d3\u904e\u7684\u4eba\u4e26\u4e0d\u80fd\u7d42\u751f\u514d\u75ab\uff0c\u53ef\u91cd\u8907\u53d7\u611f\u67d3\u3002\u6545\u5f6d\u8001\u5e2b\u5be6\u9a57\u5ba4\u9032\u884c\u66fc\u68ee\u8840\u5438\u87f2\u7684\u75ab\u82d7\u958b\u767c\u3002<\/p>\n<p style=\"text-align: justify;\">\u8981\u958b\u767c\u4e00\u500b\u75ab\u82d7\u7576\u7136\u4e0d\u662f\u5bb9\u6613\u7684\u4e8b\u60c5\uff01\u4e16\u754c\u885b\u751f\u7d44\u7e54\uff08WHO\uff09\u5df2\u9078\u5b9a\u66fc\u68ee\u8840\u5438\u87f2\u7684\u6578\u500b\u86cb\u767d\u8cea\u8a02\u70ba\u5019\u9078\u75ab\u82d7\uff0c\u5176\u4e2d\u4e00\u500b\u662f\u87f2\u9ad4\u4e0a\u7684\u8c37\u80f1\u7518\u80bd-S-\u8f49\u79fb\u9176\uff08GST\uff0cglutathione S-transferase\uff09\u3002\u96d6\u7136\u4eba\u985e\u4e5f\u6709GST\uff0c\u4f46\u4eba\u985e\u7684\u9019\u500b\u57fa\u56e0\u8207\u66fc\u68ee\u8840\u5438\u87f2\u7684\u76f8\u4f3c\u6027\u4f4e\uff0c\u6240\u4ee5\u53ef\u4ee5\u7528\u4f86\u505a\u70ba\u66fc\u68ee\u8840\u5438\u87f2\u75ab\u82d7\u7684\u6297\u539f\u3002<\/p>\n<p style=\"text-align: justify;\">\u904e\u53bb\u7684\u7814\u7a76\u5df2\u77e5\uff0c\u55ae\u7368\u4f7f\u7528\u66fc\u68ee\u8840\u5438\u87f2\u7684GST\uff0c\u6240\u505a\u51fa\u4f86\u7684\u75ab\u82d7\u5927\u6982\u670930%-50%\u7684\u4fdd\u8b77\u529b\u3002\u9019\u6a23\u7684\u75ab\u82d7\u7576\u7136\u4e0d\u4ee4\u4eba\u6eff\u610f\uff0c\u6240\u4ee5\u52a0\u5165\u4f50\u5291\u4f86\u63d0\u5347\u5bbf\u4e3b\u514d\u75ab\u53cd\u61c9\u662f\u52e2\u5728\u5fc5\u884c\u7684\u3002<\/p>\n<p style=\"text-align: justify;\">\u5f6d\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u9078\u64c7\u4e86\u75e4\u7621\u4e19\u9178\u687f\u83cc\uff08<em>Propionibacterium acnes<\/em>\uff09\u3002\u70ba\u4ec0\u9ebc\u6703\u9078\u64c7\u9019\u96bb\u7d30\u83cc\u4f86\u88fd\u4f5c\u75ab\u82d7\u7684\u4f50\u5291\u5462\uff1f\u56e0\u70ba\u5b83\u5c0d\u4eba\u5f15\u767c\u7684\u50b7\u5bb3\u4e26\u4e0d\u5927\uff0c\u7b97\u662f\u4e00\u7a2e\u76f8\u7576\u5b89\u5168\u7684\u9078\u64c7\u3002\u800c\u4e14\uff0c\u904e\u53bb\u7684\u7814\u7a76\u4e5f\u767c\u73fe\uff0c\u66fc\u68ee\u8840\u5438\u87f2\u7684GST\u4e3b\u8981\u63d0\u5347\u5bbf\u4e3b\u9ad4\u5167TH2\u514d\u75ab\u53cd\u61c9\uff0c\u4e3b\u8981\u662f\u5c0d\u6297\u611f\u67d3\u5f8c\u671f&#8211;\u6210\u87f2\u6210\u719f\u7522\u51fa\u7684\u87f2\u5375\uff0c\u4f46\u75e4\u7621\u4e19\u9178\u687f\u83cc\u53ef\u4ee5\u63d0\u5347\u5bbf\u4e3b\u7684TH1\u514d\u75ab\u53cd\u61c9\uff0c\u4f86\u4fc3\u9032\u611f\u67d3\u524d\u671f\u7684\u6bba\u87f2\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u5f6d\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u8981\u4f7f\u7528\u75e4\u7621\u4e19\u9178\u687f\u83cc\u505a\u70ba\u4f50\u5291\u3002\u4ed6\u5011\u628a\u75e4\u7621\u4e19\u9178\u687f\u83cc\u5728\u651d\u6c0f120\u5ea6\u4e0b\u52a0\u71b120\u5206\u9418\uff0c\u7136\u5f8c\u5c07\u5b83\u52a0\u5165\u66fc\u68ee\u8840\u5438\u87f2\u7684GST\u88fd\u5099\uff0c\u89c0\u5bdf\u5be6\u9a57\u52d5\u7269\uff08Balb\/c\u5c0f\u9f20\uff09\u5728\u63a5\u7a2e\u55ae\u53ea\u6709GST\u6216GST\u52a0\u4e0a\u4f50\u5291(\u71b1\u6bba\u6b7b\u75e4\u7621\u4e19\u9178\u687f\u83cc)\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n<p style=\"text-align: justify;\">\u7d50\u679c\u767c\u73fe\uff0c\u76f8\u5c0d\u65bc\u53ea\u6ce8\u5c04GST\u7d44\u7684\u52d5\u7269\uff0c\u540c\u6642\u6ce8\u5c04GST\u8207\u75e4\u7621\u4e19\u9178\u687f\u83cc\u7684\u52d5\u7269\uff0c\u5f15\u767c\u7684\u514d\u75ab\u53cd\u61c9\u6240\u7522\u751f\u7684\u4fdd\u8b77\u529b\u63d0\u9ad8\u4e86\u767e\u5206\u4e4b\u5341\u5e7e\u5230\u4e8c\u5341\uff0c\u4e5f\u5c31\u662f\u8aaa\uff0c\u540c\u6642\u6ce8\u5c04GST\u8207\u75e4\u7621\u4e19\u9178\u687f\u83cc\u7684\u52d5\u7269\uff0c\u6709\u5927\u7d0450%-70%\u7684\u4fdd\u8b77\u529b\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5229\u7528\u52a0\u71b1\u6bba\u6b7b\u7684\u75e4\u7621\u4e19\u9178\u687f\u83cc\u505a\u70ba\u4f50\u5291\uff0c\u7684\u78ba\u53ef\u4ee5\u6709\u6548\u63d0\u5347\u5bbf\u4e3b\u514d\u75ab\u53cd\u61c9\uff0c\u8b93\u75ab\u82d7\u7684\u4fdd\u8b77\u529b\u63d0\u5347\u3002<\/p>\n<p style=\"text-align: justify;\">\u9664\u4e86\u7814\u7a76\u75ab\u82d7\u7684\u4f50\u5291\uff0c\u5f6d\u8001\u5e2b\u7814\u7a76\u5ba4\u6700\u4e3b\u8981\u7684\u7814\u7a76\u8ab2\u984c\u9084\u662f\u5728\u5c0b\u627e\u53ef\u4ee5\u6297\u8840\u5438\u87f2\u6240\u9020\u6210\u7684\u809d\u7e96\u7dad\u5316\u7684\u4e2d\u85e5\uff0c\u5e0c\u671b\u80fd\u5e6b\u52a9\u4e16\u754c\u4e0a\u66f4\u591a\u7f79\u60a3\u8840\u5438\u87f2\u75c5\u7684\u75c5\u4eba\u3002<\/p>\n<p style=\"text-align: justify;\">\u53c3\u8003\u6587\u737b\uff1a<\/p>\n<p style=\"text-align: left;\">Lam HYP, Yang TH, Liang TR, Cheng PC, Chang KC, Peng SY. Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection. Acta Trop. 2021 Jul 3;222:106033. doi: 10.1016\/j.actatropica.2021.106033. Epub ahead of print. PMID: 34224719.<\/p>\n<p style=\"text-align: left;\"><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6921 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/08\/unnamed-file-1-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\uff0f\u7167\u7247\uff1a\u8449\u7da0\u8212 \u96a8\u84572019\u51a0\u72c0\u75c5\u6bd2\u75c5\u7684alpha\u8b8a\u7570\u682a\uff08 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6921,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-6920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/6920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6920"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/6920\/revisions"}],"predecessor-version":[{"id":12524,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/6920\/revisions\/12524"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/6921"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}