{"id":6445,"date":"2021-04-07T11:12:57","date_gmt":"2021-04-07T03:12:57","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=6445"},"modified":"2023-09-23T16:47:54","modified_gmt":"2023-09-23T08:47:54","slug":"%e6%85%88%e5%a4%a7%e5%8a%89%e6%80%a1%e5%9d%87%e8%b7%a8%e5%9c%8b%e7%a0%94%e7%a9%b6%e5%9c%98%e9%9a%8a%e8%a7%a3%e9%96%8b%e6%81%90%e6%87%bc%e5%89%b5%e5%82%b7%e4%b9%8b%e8%ac%8e","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=6445","title":{"rendered":"\u6148\u5927\u5289\u6021\u5747\u8de8\u570b\u7814\u7a76\u5718\u968a\u89e3\u958b\u6050\u61fc\u5275\u50b7\u4e4b\u8b0e"},"content":{"rendered":"

\u6587:\u8449\u7da0\u8212\uff0f\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78<\/span><\/p>\n

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\u5728\u773e\u591a\u53d7\u5230ATF3\u8abf\u63a7\u7684\u57fa\u56e0\u4e2d\uff0c\u5be6\u9a57\u5718\u968a\u767c\u73fe\u7a31\u70baPRDX6<\/i>\u7684\u57fa\u56e0\u662f\u8abf\u7bc0\u6050\u61fc\u7684\u95dc\u9375\u89d2\u8272\u3002PRDX6<\/i>\u5177\u6709\u78f7\u8102\u9176(<\/span>phospholipase<\/span>)\u7684\u529f\u80fd<\/span>\uff0c\u4e5f\u5c31\u662f\u8aaa\uff0c\u5b83\u53ef\u4ee5\u5206\u89e3\u4e00\u4e9b\u7d30\u80de\u819c\u4e0a\u7684\u78f7\u8102\u8cea<\/span>\uff0c\u4e5f\u5177\u6709\u6297\u6c27\u5316\u7684\u529f\u80fd\uff1b\u53e6\u5916\uff0c\u5b83\u9084\u6709\u5176\u4ed6\u7684\u4e00\u4e9b\u529f\u80fd\uff0c\u662f\u4e00\u7a2e\u591a\u529f\u80fd\u7684\u86cb\u767d\u8cea\u985e\u578b\u3002<\/span><\/p>\n

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\u627e\u5230PRDX6<\/i>\u662f\u5289\u6821\u9577\u5be6\u9a57\u5718\u968a\u6210\u529f\u7684\u7b2c\u4e00\u6b65\uff0c\u4e5f\u662f\u5f8c\u7e8c\u6df1\u5ea6\u63a2\u7d22\u5927\u8166\u61c9\u5c0d\u6050\u61fc\u7814\u7a76\u7684\u958b\u7aef\uff0c\u7531\u65bcPRDX6<\/i>\u57fa\u56e0\u5177\u6709\u8a31\u591a\u529f\u80fd\uff0c\u5289\u6821\u9577\u7684\u7814\u7a76\u5718\u968a\u672a\u4f86\u6703\u7e7c\u7e8c\u63a2\u7d22\u7a76\u7adfPRDX6<\/i>\u7684\u54ea\u4e9b\u529f\u80fd\u8207\u6050\u61fc\u8a18\u61b6\u7684\u8868\u73fe\u6bd4\u8f03\u76f8\u95dc\uff1f\u53e6\u5916\uff0c\u7576\u6211\u5011\u5c0d\u6050\u61fc\u8a18\u61b6\u7684\u8abf\u63a7\u66f4\u77ad\u89e3\u5f8c\uff0c\u662f\u5426\u80fd\u958b\u767c\u5c0f\u5206\u5b50\u85e5\u7269\u6cbb\u7642PTSD\uff1f\u56e0\u70ba\u7576\u524d\u81e8\u5e8a\u4e0a\u5c0d\u65bcPTSD\u7684\u4e3b\u8981\u6cbb\u7642\u65b9\u5f0f\u662f\u63d0\u4f9b\u93ae\u975c\u5291\u7d66\u60a3\u8005\u4f7f\u7528\uff0c\u4f46\u6b64\u9805\u6cbb\u7642\u65b9\u5f0f\u672a\u80fd\u5c0d\u6bcf\u500b\u60a3\u8005\u90fd\u7522\u751f\u6709\u6548\u6cbb\u7642\uff1b\u56e0\u6b64\u5982\u679c\u80fd\u958b\u767c\u51fa\u91dd\u5c0dPRDX6\u7684<\/i>\u5c0f\u5206\u5b50\u85e5\u7269\u4ee5\u6cbb\u7642PTSD\uff0c\u5c07\u662f\u4e00\u7a2e\u7cbe\u6e96\u7642\u6cd5\uff1b\u5c0d\u65bc\u5354\u52a9\u9019\u4e9b\u60a3\u8005\u91cd\u65b0\u56de\u5230\u793e\u6703\u3001\u518d\u5ea6\u767c\u63ee\u4eba\u751f\u7684\u826f\u80fd\uff0c\u5c07\u6709\u6b63\u9762\u7a4d\u6975\u7684\u52a9\u76ca\u3002<\/span><\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n

Sarayut Phasuk, Tanita Pairojana, Pavithra Suresh, Chee-Hing Yang, Sittiruk Roytrakul, Shun-Ping Huang, Chien-Chang Chen, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi & Ingrid Y. Liu*. Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway. Molecular Brain, IF 4.686. 2021 ( DOI: 10.1186\/s13041-021-00754-1).<\/span><\/p>\n

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