{"id":6425,"date":"2021-04-07T11:06:20","date_gmt":"2021-04-07T03:06:20","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=6425"},"modified":"2023-09-23T16:46:53","modified_gmt":"2023-09-23T08:46:53","slug":"%e6%85%88%e5%a4%a7%e6%9e%97%e5%85%89%e6%85%a7%e7%a0%94%e7%a9%b6%e9%99%a2%e5%85%a7%e6%84%9f%e6%9f%93%e7%ac%ac%e4%b8%80%e7%9a%84%e9%ae%91%e6%b0%8f%e4%b8%8d%e5%8b%95%e6%a1%bf%e8%8f%8c%e6%8a%97%e6%80%a7","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=6425","title":{"rendered":"\u6148\u5927\u6797\u5149\u6167\u7814\u7a76\u9662\u5167\u611f\u67d3\u7b2c\u4e00\u7684\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u6297\u6027\u6a5f\u5236"},"content":{"rendered":"<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\">\u6587:\u8449\u7da0\u8212\uff0f\u7167\u7247:\u6148\u6fdf\u5927\u5b78<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u751f\u7269\u751f\u5b58\u5728\u9019\u500b\u4e16\u754c\u4e0a\uff0c\u514d\u4e0d\u4e86\u6703\u9047\u5230\u9006\u5883\u3002\u5c0d\u65bc\u4fd7\u7a31AB\u83cc\u3001\u9020\u6210\u5f9e2012\u5e74\u52302016\u5e74\u53f0\u7063\u9662\u5167\u611f\u67d3\u6e90\u7684\u7b2c\u4e00\u4f4d\u7684\u300c\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\uff08<i>Acinetobacter baumannii<\/i>\uff09\u300d\u4f86\u8aaa\uff0c\u4e5f\u662f\u4e00\u6a23\u3002\u75c5\u83cc\u611f\u67d3\u6211\u5011\u7684\u6642\u5019\uff0c\u6211\u5011\u4e00\u5b9a\u6703\u6295\u4ee5\u6297\u751f\u7d20\u4f86\u9032\u884c\u6cbb\u7642\uff0c\u800c\u4eba\u9ad4\u5167\u7684\u514d\u75ab\u7cfb\u7d71\u4e5f\u6703\u51fa\u52d5\u4f86\u653b\u64ca\u5165\u4fb5\u7684\u75c5\u83cc\u3002\u9019\u6642\u5019\uff0c\u75c5\u83cc\u662f\u5426\u80fd\u751f\u5b58\u4e0b\u53bb\uff0c\u5c31\u8981\u770b\u75c5\u83cc\u672c\u8eab\u7684\u62b5\u6297\u529b\u5920\u4e0d\u5920\u5f37\u4e86\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u7576\u6297\u751f\u7d20\u6216\u662f\u5de8\u566c\u7d30\u80de\uff08macrophage\uff09\u9047\u5230\u75c5\u83cc\u6642\uff0c\u90fd\u6703\u6709\u6240\u8b02\u7684\u300c\u6709\u6a5f\u904e\u6c27\u5316\u7269\u300d\uff08organic peroxide\uff09\u7684\u7522\u751f\u3002\u9019\u4e9b\u6709\u6a5f\u904e\u6c27\u5316\u7269\u6703\u5c0d\u75c5\u83cc\u9020\u6210\u50b7\u5bb3\uff0c\u4f7f\u75c5\u83cc\u6b7b\u4ea1\u3002\u4f46\u662f\u6709\u4e9b\u75c5\u83cc\u537b\u53ef\u4ee5\u7522\u751f\u5206\u89e3\u6709\u6a5f\u904e\u6c27\u5316\u7269\u7684\u9175\u7d20\uff0c\u8b93\u81ea\u5df1\u53ef\u4ee5\u4e0d\u53d7\u5230\u9019\u4e9b\u6709\u6a5f\u904e\u6c27\u5316\u7269\u7684\u50b7\u5bb3\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u570b\u969b\u66a8\u8de8\u9818\u57df\u5b78\u9662\u9662\u9577\u6797\u5149\u6167\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\uff0c\u8207\u9577\u69ae\u5927\u5b78\u7684\u8a31\u9d3b\u7337\u526f\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\uff0c\u591a\u5e74\u4f86\u4e00\u76f4\u5728\u7814\u7a76\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u62b5\u6297\u6709\u6a5f\u904e\u6c27\u5316\u7269\u7684\u6a5f\u5236\u3002\u6797\u5149\u6167\u6559\u6388\u8aaa\uff0c\u6703\u8e0f\u5165\u9019\u500b\u9818\u57df\u5176\u5be6\u662f\u56e0\u7de3\u969b\u6703\uff1b\u7576\u521d\u539f\u672c\u662f\u767c\u73fe\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u6703\u5206\u89e3\u5432\u54da\u4e59\u9178\uff08IAA\uff0c\u70ba\u690d\u7269\u7684\u8cc0\u723e\u8499\u4e4b\u4e00\uff09\uff0c\u5f8c\u4f86\u5728\u7814\u7a76\u5206\u89e3\u5432\u54da\u4e59\u9178\u7684\u57fa\u56e0\u7684\u540c\u6642\uff0c\u4e5f\u767c\u73fe\u4e86\u9019\u500b\u6709\u53ef\u4ee5\u5206\u89e3\u904e\u6c27\u5316\u7269\u7684\u57fa\u56e0\uff0c\u5c31\u9019\u9ebc\u8e0f\u5165\u4e86\u9019\u500b\u9818\u57df\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6797\u5149\u6167\u6559\u6388\u8868\u793a\uff0c\u8ca0\u8cac\u5206\u89e3\u6709\u6a5f\u904e\u6c27\u5316\u7269\u7684\u57fa\u56e0\u7a31\u70ba<i>ohr<\/i>\uff0c\u5b83\u7684\u65c1\u908a\u6709\u53e6\u4e00\u500b\u57fa\u56e0\u8ca0\u8cac\u8abf\u7bc0\u5b83\u7684\u8868\u73fe\uff0c\u7a31\u70ba<i>ohrR<\/i>\u3002\u7576\u6c92\u6709\u6709\u6a5f\u904e\u6c27\u5316\u7269\u5b58\u5728\u6642\uff0cOhrR\u86cb\u767d\u6703\u906e\u4f4f<i>ohr<\/i>\u57fa\u56e0\u7684\u555f\u52d5\u5b50\u5340\u57df\uff0c\u8b93<i>ohr<\/i>\u57fa\u56e0\u7121\u6cd5\u8868\u73fe\u3002\u6709\u6a5f\u904e\u6c27\u5316\u7269\u51fa\u73fe\u5f8c\uff0c\u6703\u6539\u8b8aOhrR\u86cb\u767d\u8cea\u7684\u7d50\u69cb\uff0c\u4f7f\u5b83\u96e2\u958b<i>ohr<\/i>\u57fa\u56e0\u7684\u555f\u52d5\u5b50\uff0c\u65bc\u662f<i>ohr<\/i>\u57fa\u56e0\u5c31\u958b\u59cb\u8868\u73fe\uff0c\u6709\u6a5f\u904e\u6c27\u5316\u7269\u5c31\u88ab\u5206\u89e3\u4e86\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u6709\u975e\u5e38\u591a\u4e0d\u540c\u7684\u5206\u96e2\u682a\uff0c\u7814\u7a76\u5718\u968a\u5728\u5176\u4e2d\u4e00\u500b\u5206\u96e2\u682a\uff08ATCC19606\uff09\u4e2d\u767c\u73fe\u4e86\u4e00\u500b\u8cea\u9ad4pMAC\uff0c\u4e0a\u9762\u4e5f\u540c\u6642\u5e36\u6709<i>ohrR<\/i>\u8207<i>ohr<\/i>\u57fa\u56e0\u3002\u53ef\u662f\u67d3\u8272\u9ad4\u4e0a\u9762\u4e5f\u5e36\u6709<i>ohrR<\/i>\u8207<i>ohr<\/i>\u57fa\u56e0\u554a\uff01\u70ba\u4f55\u8981\u5e36\u529f\u80fd\u76f8\u540c\u7684\u5169\u4efd\u57fa\u56e0\u5462\uff1f\u9019\u5c31\u8b93\u4eba\u5f88\u597d\u5947\u4e86\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u7814\u7a76\u5718\u968a\u5728\u6e2c\u8a66\u4e2d\u767c\u73fe\uff0c\u591a\u5e36\u4e86\u4e00\u4efd<i>ohr<\/i>\u57fa\u56e0\uff0c\u4e26\u4e0d\u6703\u4f7f\u7d30\u83cc\u5c0d\u6709\u6a5f\u904e\u6c27\u5316\u7269\u7684\u6297\u6027\u63d0\u9ad8\u3002\u63a5\u8457\u7814\u7a76\u5718\u968a\u60f3\u628a19606\u5206\u96e2\u682a\u7684\u8cea\u9ad4\u7d66\u62ff\u6389\uff0c\u4f46\u662f\u4e0d\u7ba1\u600e\u9ebc\u5617\u8a66\u90fd\u6c92\u6709\u8fa6\u6cd5\u3002\u7531\u65bc\u5176\u4ed6\u7814\u7a76\u5718\u968a\u4e5f\u9047\u5230\u76f8\u540c\u7684\u56f0\u96e3\uff0c\u65bc\u662f\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u5229\u7528\u53e6\u4e00\u500b\u539f\u672c\u5c31\u6c92\u6709\u8cea\u9ad4\u7684\u5206\u96e2\u682a17978\u4f86\u505a\u70ba\u5c0d\u7167\u7d44\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u7814\u7a76\u5718\u968a\u628a\u9019\u5169\u500b\u5206\u96e2\u682a\u7684<i>ohrR<\/i>\u8207<i>ohr<\/i>\u57fa\u56e0\u5206\u5225\u5254\u9664\uff0c\u7522\u751f\u5c11\u4e86\u4e00\u500b\u57fa\u56e0\uff08<i>ohrR<\/i>\u6216<i>ohr<\/i>\uff09\u6216\u540c\u6642\u7f3a\u5c11\u5169\u500b\u57fa\u56e0\u7684\u7a81\u8b8a\u7d30\u83cc\u3002\u7d50\u679c\u767c\u73fe\uff0c\u5c11\u4e86\u5169\u500b\u57fa\u56e0\u768419606\u5206\u96e2\u682a\u6d3b\u5f97\u5f88\u597d\uff0c\u4f46\u5c11\u4e86\u5169\u500b\u57fa\u56e0\u768417978\u5206\u96e2\u682a\u537b\u9577\u5f97\u6bd4\u8f03\u6162\u3002\u7531\u65bc\u7d30\u83cc\u5728\u8907\u88fd\u81ea\u5df1\u7684\u67d3\u8272\u9ad4\u6642\u4e5f\u6703\u7522\u751f\u5c11\u91cf\u7684\u6709\u6a5f\u904e\u6c27\u5316\u7269\uff0c\u9019\u500b\u7d50\u679c\u986f\u793a\u4e86\uff0c\u4f4d\u65bc\u8cea\u9ad4\u4e0a\u7684<i>ohr<\/i>\u57fa\u56e0\uff0c\u5c0d\u7d30\u83cc\u7684\u5b58\u6d3b\u5ea6\u7522\u751f\u4e86\u5f71\u97ff\u3002\u9032\u4e00\u6b65\u7684\u6e2c\u8a66\u767c\u73fe\uff0c\u5c11\u4e86\u5169\u500b\u57fa\u56e0\u768417978\u5206\u96e2\u682a\uff0c\u4e0d\u50c5\u6703\u88ab\u904e\u6c27\u5316\u53d4\u4e01\u9187\uff08<i>tert<\/i>-butyl hydroperoxide\uff0c<i>t<\/i>BHP\uff0c\u4e00\u7a2e\u5be6\u9a57\u7528\u7684\u6709\u6a5f\u904e\u6c27\u5316\u7269\uff09\u7d66\u6bba\u6b7b\u3001\u5c0d\u6297\u751f\u7d20\u7684\u654f\u611f\u6027\u4e0a\u5347\uff0c\u4e5f\u7121\u6cd5\u611f\u67d3\u5927\u881f\u86fe\u7684\u5e7c\u87f2\uff0c\u986f\u793a\u4e86\u5c11\u4e86\u9019\u5169\u500b\u57fa\u56e0\u5c0d\u7d30\u83cc\u7684\u5f71\u97ff\u5f88\u5927\uff1b\u4f46\u5c11\u4e86\u9019\u5169\u500b\u57fa\u56e0\u768419606\u5206\u96e2\u682a\u537b\u4e0d\u53d7\u5f71\u97ff\uff0c\u610f\u5473\u8457\u96d6\u7136\u4f4d\u65bc\u8cea\u9ad4\u4e0a\u7684\u90a3\u5169\u500b\u57fa\u56e0\u4e26\u4e0d\u6703\u8b93\u7d30\u83cc\u672c\u8eab\u7684\u6297\u6027\u4e0a\u5347\uff0c\u4f46\u5728\u67d3\u8272\u9ad4\u4e0a\u7f3a\u5c11\u4e86\u9019\u5169\u500b\u57fa\u56e0\u6642\uff0c\u4f4d\u65bc\u8cea\u9ad4\u4e0a\u7684\u57fa\u56e0\u537b\u80fd\u5920\u767c\u63ee\u88dc\u4f4d\u7684\u6548\u80fd\uff0c\u8b93\u7d30\u83cc\u7e7c\u7e8c\u5805\u5f37\u5730\u751f\u5b58\u4e0b\u53bb\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u5e8f\u5217\u7684\u5206\u6790\u767c\u73fe\uff0c\u4f4d\u65bc\u8cea\u9ad4\u4e0a\u7684\u9019\u5169\u500b\u57fa\u56e0\u8ddf\u67d3\u8272\u9ad4\u4e0a\u7684\u96d6\u7136\u76f8\u4f3c\uff0c\u4f46\u76f8\u4f3c\u5ea6\u4e26\u4e0d\u662f\u90a3\u9ebc\u9ad8\uff0c\u986f\u793a\u4e86\u8cea\u9ad4\u4e0a\u7684\u57fa\u56e0\u53ef\u80fd\u662f\u5f9e\u5176\u4ed6\u7d30\u83cc\u7d93\u7531\u5e73\u884c\u57fa\u56e0\u8f49\u79fb\u5f97\u4f86\u7684\u3002\u96d6\u7136\u9019\u5169\u500b\u57fa\u56e0\u4e0d\u662f\u6c7a\u5b9a\u6297\u85e5\u6027\u7684\u4e3b\u8981\u57fa\u56e0\uff0c\u4f46\u7814\u7a76\u5718\u968a\u7684\u6210\u679c\u986f\u793a\uff0c\u5b83\u5011\u9084\u662f\u5c0d\u6297\u85e5\u6027\u6709\u5f88\u5927\u7684\u8ca2\u737b\u3002\u7814\u7a76\u5718\u968a\u8a8d\u70ba\uff0c\u5982\u679c\u53bb\u7814\u7a76\u91ab\u9662\u5167\u7684\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\uff0c\u53ef\u80fd\u5176\u4e2d\u5927\u90e8\u5206\u90fd\u542b\u6709\u9019\u500b\u8cea\u9ad4\u3002\u900f\u904e\u9019\u500b\u7814\u7a76\uff0c\u6211\u5011\u4e5f\u5c0d\u9b91\u6c0f\u4e0d\u52d5\u687f\u83cc\u7684\u6297\u85e5\u6027\u6709\u4e86\u9032\u4e00\u6b65\u7684\u8a8d\u8b58\u3002<\/span><\/p>\n<p class=\"p5\" style=\"text-align: justify;\"><span class=\"s1\">\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n<p class=\"p5\" style=\"text-align: justify;\"><span class=\"s1\">Chen, S.-J.; Shu, H.-Y.; Lin, G.-H. Regulation of <i>tert<\/i>-Butyl Hydroperoxide Resistance by Chromosomal OhrR in <i>A. baumannii<\/i> ATCC 19606. Microorganisms 2021, 9, 629. https:\/\/doi.org\/10.3390\/microorganisms9030629<\/span><\/p>\n<p><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6426 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/unnamed-file-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6427 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/1-2-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6428 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2.jpg\" alt=\"\" width=\"1024\" height=\"1366\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2-225x300.jpg 225w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2-768x1025.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2-730x974.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/2-2-435x580.jpg 435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/3-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-6429 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2021\/04\/3-2.jpg\" alt=\"\" width=\"1024\" height=\"683\" 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