{"id":6300,"date":"2021-03-10T14:34:16","date_gmt":"2021-03-10T06:34:16","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=6300"},"modified":"2023-09-23T16:39:10","modified_gmt":"2023-09-23T08:39:10","slug":"%e6%85%88%e5%a4%a7%e8%98%87%e4%bc%af%e7%90%a6%e7%a0%94%e7%a9%b6%e5%85%8b%e9%9b%b7%e4%bc%af%e6%b0%8f%e8%82%ba%e7%82%8e%e6%a1%bf%e8%8f%8c%e8%88%87%e8%82%9d%e8%86%bf%e7%98%8d%e9%97%9c%e4%bf%82","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=6300","title":{"rendered":"\u6148\u5927\u8607\u4f2f\u7426\u7814\u7a76\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u687f\u83cc\u8207\u809d\u81bf\u760d\u95dc\u4fc2"},"content":{"rendered":"

\u6587:\u8449\u7da0\u8212\uff0f\u7167\u7247:\u8449\u7da0\u8212\u3001\u8607\u4f2f\u7426<\/span><\/p>\n

\u8207\u5927\u8178\u687f\u83cc\u662f\u89aa\u621a\u7684\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u687f\u83cc\uff08<\/span>Klebsiella pneumoniae<\/i><\/span>\uff09\u662f\u6211\u5011\u53e3\u8154\u3001\u76ae\u819a\u3001\u8178\u9053\u7684\u6b63\u5e38\u83cc\u53e2\uff0c\u4f46\u7576\u5b83\u8dd1\u5230\u5176\u4ed6\u5668\u5b98\uff0c\u90a3\u5c31\u6703\u5f15\u8d77\u56b4\u91cd\u7684\u75be\u75c5\uff0c\u5982\uff1a\u80ba\u708e\u3001\u5c3f\u8def\u611f\u67d3\u3001\u809d\u81bf\u760d\u7b49\u3002\u7531\u5b83\u5f15\u8d77\u7684\u809d\u81bf\u760d\uff0c\u5df2\u7531\u65e9\u5e74\u7684\u4e09\u6210\u4f86\u5230\u516b\u6210\uff1b\u800c\u7cd6\u5c3f\u75c5\u75c5\u4eba\u7684\u809d\u81bf\u760d\u66f4\u6709\u4e5d\u6210\u90fd\u8207\u5b83\u6709\u95dc\u3002<\/span><\/p>\n

\u4e5f\u5c31\u662f\u56e0\u70ba\u5982\u6b64\uff0c\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u6aa2\u9a57\u66a8\u751f\u7269\u6280\u8853\u7cfb\u7684\u8607\u4f2f\u7426\u8001\u5e2b\u8207\u4ed6\u7684\u7814\u7a76\u5718\u968a\uff0c\u9078\u64c7\u7814\u7a76\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u687f\u83cc\u505a\u70ba\u4ed6\u5011\u7684\u4e2d\u5fc3\u8b70\u984c\u3002\u9019\u96bb\u83cc\u6709\u5169\u5957\u7e96\u6bdb\u7cfb\u7d71\uff08\u7b2c\u4e00\u578b\u548c\u7b2c\u4e09\u578b\uff09\uff0c\u5176\u4e2d\u7b2c\u4e09\u578b\u7e96\u6bdb\u4e3b\u8981\u5e6b\u52a9\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u687f\u83cc\u9644\u8457\u5728\u5c0e\u7ba1\u8868\u9762\uff08\u4f8b\u5982\u5c0e\u5c3f\u7ba1\uff09\uff0c\u7b2c\u4e00\u578b\u7e96\u6bdb\u4e3b\u8981\u9644\u8457\u5728\u542b\u6709\u7518\u9732\u7cd6\u7684\u7d30\u80de\u8868\u9762\u3002\u9664\u4e86\u9644\u8457\u7684\u80fd\u529b\u5c0d\u5b83\u7684\u81f4\u75c5\u80fd\u529b\u5f88\u91cd\u8981\u5916\uff0c\u9019\u96bb\u83cc\u9084\u6709\u7531\u591a\u91a3\u69cb\u6210\u7684\u539a\u539a\u7684\u83a2\u819c\u5916\u5957\uff08<\/span>CPS<\/span>\uff0c<\/span>capsular polysaccharide<\/span>\uff09\u7528\u4f86\u4fdd\u8b77\u81ea\u5df1\u3002\u83a2\u819c\u5916\u5957\u53ef\u4f7f\u7d30\u83cc\u8b8a\u5f97\u4e0d\u5bb9\u6613\u88ab\u5bbf\u4e3b\uff08\u6bd4\u5982\uff1a\u4eba\u985e\uff09\u7684\u541e\u566c\u7d30\u80de\u541e\u98df\uff0c\u4e5f\u53ef\u4fdd\u8b77\u7d30\u83cc\u4e0d\u53d7\u5230\u6d88\u6bd2\u5291\uff08\u5982\u96d9\u6c27\u6c34\uff09\u7684\u50b7\u5bb3\u3002<\/span><\/p>\n

\u6700\u8fd1\u8607\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\u4e86\u4e00\u500b\u57fa\u56e0\uff0c\u8207\u7e96\u6bdb\u7cfb\u7d71\u53ca\u83a2\u819c\u5f62\u6210\u90fd\u6709\u95dc\u3002\u9019\u500b\u57fa\u56e0\u5c6c\u65bc\u7d30\u83cc\u7684\u78f7\u9178\u8f49\u79fb\u7cfb\u7d71\uff08<\/span>PTS<\/span>\uff0c<\/span>phosphoenolpyruvate (PEP)-dependent phosphotransferase system<\/span>\uff09\u4e4b\u4e00\u3002\u7576\u9019\u500b\u57fa\u56e0\uff08<\/span>crr<\/i><\/span>\uff09\u7f3a\u4e4f\u6642\uff0c\u6703\u9020\u6210\u53e6\u5916\u4e09\u500b\u57fa\u56e0\uff08<\/span>galF<\/i><\/span>\uff0c<\/span>wzi<\/i><\/span>\u8207<\/span>gnd<\/i><\/span>\uff09\u7684\u8868\u73fe\u91cf\u4e0a\u5347\uff0c\u9020\u6210\u7d30\u83cc\u64c1\u6709\u7279\u5225\u539a\u7684\u83a2\u819c\u5916\u5957\uff01\u9019\u500b\u7a7f\u5927\u5916\u5957\u7684\u7d30\u83cc\u7a81\u8b8a\u682a\uff0c\u4e0d\u50c5\u5728<\/span>1%<\/span>\u7684\u96d9\u6c27\u6c34\u4e2d\u7684\u5b58\u6d3b\u7387\u4e0a\u5347\uff0c\u88ab\u5de8\u566c\u7d30\u80de\uff08<\/span>macrophage<\/span>\uff09\u541e\u566c\u7684\u91cf\u4e5f\u8b8a\u5c11\u3001\u541e\u566c\u5f8c\u7684\u5b58\u6d3b\u7387\u4e5f\u4e0a\u5347\u4e86\u3002<\/span><\/p>\n

\u7531\u65bc<\/span>PTS<\/span>\u8207\u7e96\u6bdb\u7cfb\u7d71\u6709\u95dc\uff0c\u800c\u904e\u53bb\u8607\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u66fe\u767c\u73fe\u4e00\u500b\u65b0\u578b\u7684<\/span>PTS<\/span>\u7a31\u70ba<\/span>etcABC<\/i><\/span>\uff0c\u65bc\u662f\u8607\u8001\u5e2b\u6c7a\u5b9a\u53bb\u770b\u770b\u5230\u5e95\u9019\u500b<\/span>crr<\/i><\/span>\u57fa\u56e0\u662f\u5426\u8207<\/span>etcABC<\/i><\/span>\u6709\u95dc\u3002\u6709\u8da3\u7684\u662f\uff0c\u7576\u4ed6\u5011\u5728<\/span>crr<\/i><\/span>\u7a81\u8b8a\u682a\u4e2d\u53bb\u6389<\/span>etcABC<\/i><\/span>\u6642\uff0c\u53e6\u4e00\u500b\u57fa\u56e0<\/span>galF<\/i><\/span>\u7684\u8868\u73fe\u91cf\u4e0b\u964d\uff0c\u800c\u7d30\u83cc\u7684\u83a2\u819c\u5916\u5957\u5c31\u8b8a\u8584\u4e86\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u904e\u53bb\u767c\u73fe<\/span>etcABC<\/i><\/span>\u8207\u7b2c\u4e09\u578b\u7e96\u6bdb\u7684\u8868\u73fe\u6709\u95dc\uff0c\u9019\u6b21\u7684\u7814\u7a76\u6210\u679c\u9032\u4e00\u6b65\u767c\u73fe\uff0c<\/span>etcABC<\/i><\/span>\u8207\u83a2\u819c\u7684\u7522\u51fa\u4e5f\u6709\u95dc\u4fc2\uff1b\u800c\u96b8\u5c6c\u65bc\u53e6\u4e00\u500b<\/span>PTS<\/span>\u7684<\/span>crr<\/i><\/span>\u57fa\u56e0\uff0c\u7adf\u7136\u4e5f\u80fd\u85c9\u7531\u6291\u5236<\/span>etcABC<\/i><\/span>\u9019\u500b<\/span>PTS<\/span>\u4f86\u8abf\u7bc0\u7d30\u83cc\u7684\u83a2\u819c\u591a\u91a3\u7684\u7522\u751f\uff0c\u5f9e\u800c\u5f71\u97ff\u7d30\u83cc\u83a2\u819c\u7684\u539a\u5ea6\u3002<\/span><\/p>\n

\u672a\u4f86\u8607\u8001\u5e2b\u7684\u7814\u7a76\u5718\u968a\u5e0c\u671b\u80fd\u5f9e\u7814\u7a76<\/span>crr<\/i><\/span>\u8207<\/span>etcABC<\/i><\/span>\u7684\u4e92\u52d5\uff0c\u9032\u4e00\u6b65\u77ad\u89e3\u514b\u96f7\u4f2f\u6c0f\u80ba\u708e\u687f\u83cc\u662f\u5982\u4f55\u6b66\u88dd\u81ea\u5df1\uff0c\u7531\u6b64\u4f86\u77ad\u89e3\u70ba\u4f55\u7cd6\u5c3f\u75c5\u75c5\u4eba\u7684\u809d\u81bf\u760d\u6709\u6975\u9ad8\u6bd4\u4f8b\u90fd\u8207\u9019\u96bb\u7d30\u83cc\u6709\u95dc\u3002<\/span><\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n

Panjaitan NSD, Horng YT, Chien CC, Yang HC, You RI, Soo PC. The PTS Components in Klebsiella pneumoniae Affect Bacterial Capsular Polysaccharide Production and Macrophage Phagocytosis Resistance. Microorganisms. 2021 Feb 8;9(2):335. doi: 10.3390\/microorganisms9020335. PMID: 33567595.<\/span><\/p>\n

\"\"<\/a> \"\"<\/a> \"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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