{"id":5058,"date":"2020-04-22T09:22:05","date_gmt":"2020-04-22T01:22:05","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=5058"},"modified":"2023-09-23T11:17:58","modified_gmt":"2023-09-23T03:17:58","slug":"%e6%85%88%e5%a4%a7%e9%a1%8f%e7%91%9e%e9%b4%bb%e7%a0%94%e7%a9%b6%e5%9c%98%e9%9a%8a%e7%82%ba%e7%99%8c%e7%97%87%e7%9a%84%e6%b2%bb%e7%99%82%e6%8f%90%e4%be%9b%e6%96%b0%e6%96%b9%e5%90%91","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=5058","title":{"rendered":"\u6148\u5927\u984f\u745e\u9d3b\u7814\u7a76\u5718\u968a\u70ba\u764c\u75c7\u7684\u6cbb\u7642\u63d0\u4f9b\u65b0\u65b9\u5411"},"content":{"rendered":"<p class=\"p1\" style=\"text-align: justify;\"><span class=\"s1\">\u6587\uff1a\u8449\u7da0\u8212\uff0f\u5716\uff1a\u6797\u54f2\u5148<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u984f\u745e\u9d3b\u6559\u6388\u7814\u7a76\u5718\u968a\uff0c\u7e7c\u53bb\u5e74\u767c\u73fe\u5b58\u5728\u65bc\u67d1\u6a58\u76ae\u4e2d\u7684\u5ddd\u9673\u76ae\u7d20\uff08NOB\uff0cnobiletin\uff09\u5c0d\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u6709\u6291\u5236\u7684\u529f\u6548\uff0c\u4eca\u5e74\u66f4\u9032\u4e00\u6b65\u767c\u73fe\u5ddd\u9673\u76ae\u7d20\u53ef\u4ee5\u4f5c\u70ba\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7684\u8f14\u52a9\u7642\u6cd5\u7684\u65b0\u6210\u54e1\u4e4b\u4e00\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08CML\uff0cchronic myelogenous leukemia\uff09\u662f\u9aa8\u9ad3\u589e\u751f\u6027\u75be\u75c5\uff08myeloproliferative disorder\uff09\u7684\u4e00\u7a2e\u3002\u60a3\u8005\u9ad4\u5167\u7684\u767d\u8840\u7403\u6703\u51fa\u73fe\u4e0d\u6b63\u5e38\u7684\u589e\u751f\u73fe\u8c61\u3002\u60a3\u8005\u901a\u5e38\u7121\u660e\u986f\u75c7\u72c0\uff0c\u53ef\u80fd\u6709\u7570\u5e38\u51fa\u8840\u9ede\u3001\u813e\u81df\u816b\u5927\u3001\u4e0d\u660e\u8179\u75db\u6216\u75b2\u5026\u3002\u5e38\u5728\u6aa2\u67e5\u6642\u610f\u5916\u767c\u73fe\u767d\u8840\u7403\u7570\u5e38\u589e\u52a0\uff0c\u624d\u77e5\u9053\u81ea\u5df1\u5f97\u4e86\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u3002\u5728\u53f0\u7063\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7684\u767c\u751f\u7387\u662f\u6bcf\u5e74\u6bcf\u5341\u842c\u4eba\u7d04\u67091.3\u4eba\u5f97\u75c5\uff0c\u5b83\u5bb9\u6613\u5728\u4e2d\u8001\u5e74\u4eba\u7522\u751f\uff0c\u5982\u679c\u4e0d\u6cbb\u7642\u7684\u8a71\u5b58\u6d3b\u7387\u5e73\u5747\u70ba\u56db\u5e74\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u662f\u7b2c\u4e00\u500b\u88ab\u767c\u73fe\u8207\u660e\u986f\u7684\u907a\u50b3\u7570\u5e38\u6709\u95dc\u7684\u764c\u75c7\uff0c\u767e\u5206\u4e4b\u4e5d\u5341\u5230\u4e5d\u5341\u4e94\u7684\u75c5\u4eba\u6703\u51fa\u73fe\u300c\u8cbb\u57ce\u67d3\u8272\u9ad4\uff08Philadelphia Chromosome\uff09\u300d\uff1a\u7b2c9\u5c0d\u4ee5\u53ca\u7b2c22\u5c0d\u67d3\u8272\u9ad4\u8f49\u4f4d\uff08\u5beb\u505at(9:22)\uff09\uff0c\u4f7f\u5f97\u539f\u5148\u4f4d\u65bc\u7b2c9\u5c0d\u67d3\u8272\u9ad4\u53d7\u5230\u7dca\u5bc6\u8abf\u63a7\u7684ABL\u539f\u764c\u57fa\u56e0\u88ab\u8f49\u4f4d\u5230\u7b2c22\u5c0d\u67d3\u8272\u9ad4BCR\u57fa\u56e0\u4e0a\uff0c\u9020\u6210\u8a72\u57fa\u56e0\uff08ABL\u662f\u4e00\u500b\u916a\u80fa\u9178\u6fc0\u9176\uff0ctyrosine kinase\uff09\u904e\u5ea6\u8868\u73fe\u3002\u76ee\u524d\u81e8\u5e8a\u4e0a\u5df2\u6709\u5065\u4fdd\u7d66\u4ed8\u4e4b\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff0ctyrosine kinase inhibitor\uff09\uff0c\u5982\u57fa\u5229\u514b\uff08imatinib\uff09\u3001\u6cf0\u606f\u5b89\uff08nilotinib\uff09\u7b49\u53ef\u4ee5\u7528\u4f86\u6cbb\u7642\u3002\u53ea\u8981\u597d\u597d\u63a7\u5236\uff0c\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c58\u5e74\u5b58\u6d3b\u7387\u53ef\u9ad8\u9054\u4e5d\u6210\u4ee5\u4e0a\uff0c\u591a\u6578\u60a3\u8005\u53ef\u5b58\u6d3b\u8d85\u904e10\u523020\u5e74\u3002\u96d6\u7136\u5982\u6b64\uff0c\u4f46\u4ecd\u6709\u4e00\u5b9a\u6bd4\u4f8b\u7684\u60a3\u8005\u6703\u5c0d\u9019\u4e9b\u916a\u80fa\u9178\u6fc0\u9176\u6291\u5236\u5291\u7522\u751f\u6297\u6027\u3002\u5982\u80fd\u4ee5\u5176\u4ed6\u85e5\u7269\u4f86\u88dc\u5145\uff0c\u9054\u6210\u964d\u4f4e\u85e5\u7269\u4f7f\u7528\u91cf\uff0c\u5247\u53ef\u9054\u6210\u9810\u9632\u60a3\u8005\u5c0d\u85e5\u7269\u7522\u751f\u6297\u6027\u7684\u6548\u679c\u3002\u56e0\u6b64\u5728\u81e8\u5e8a\u4e0a\u6709\u6240\u8b02\u7684\u8f14\u52a9\u7642\u6cd5\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u7684\u984f\u745e\u9d3b\u6559\u6388\u7684\u5be6\u9a57\u5ba4\uff0c\u8207\u82b1\u84ee\u6148\u6fdf\u91ab\u9662\u907a\u50b3\u8aee\u8a62\u4e2d\u5fc3\u7d30\u80de\u907a\u50b3\u5ba4\u9673\u4f69\u6021\u4e3b\u4efb\u5408\u4f5c\uff0c\u9577\u671f\u81f4\u529b\u65bc\u958b\u767c\u53ef\u9032\u884c\u767d\u8840\u75c5\u8f14\u52a9\u7642\u6cd5\u7684\u5929\u7136\u852c\u679c\u690d\u5316\u7d20\uff0c\u5c24\u5176\u5c0d\u67d1\u6a58\u985e\u690d\u7269\u7684\u985e\u9ec3\u916e\u7d20\u7279\u5225\u611f\u8208\u8da3\u3002\u53bb\u5e74\u984f\u6559\u6388\u7814\u7a76\u5718\u968a\u767c\u73fe\u5b58\u5728\u65bc\u67d1\u6a58\u76ae\u4e2d\u7684\u5ddd\u9673\u76ae\u7d20\uff08NOB\uff0cnobiletin\uff09\u5c0d\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u6709\u6291\u5236\u7684\u529f\u6548\uff0c\u4eca\u5e74\u518d\u63a5\u518d\u52f5\uff0c\u9032\u4e00\u6b65\u767c\u73fe\u5ddd\u9673\u76ae\u7d20\u53ef\u4ee5\u4f5c\u70ba\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7684\u8f14\u52a9\u7642\u6cd5\u7684\u65b0\u6210\u54e1\u4e4b\u4e00\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u984f\u6559\u6388\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u5c07\u4eba\u985e\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7d30\u80de\u682aK562\u4ee5100\u5fae\u83ab\u8033\uff08<\/span><span class=\"s2\">\u03bc<\/span><span class=\"s1\">M\uff09\u7684\u5ddd\u9673\u76ae\u7d20\u8655\u7406\u4e00\u5929\u5f8c\uff0c\u764c\u7d30\u80de\u7684\u751f\u9577\u4e0b\u964d\u4e86\u5927\u7d04\u4e00\u534a\u3002\u9019\u500b\u6fc3\u5ea6\u7684\u5ddd\u9673\u76ae\u7d20\u5c0d\u6b63\u5e38\u7d30\u80de\u662f\u6c92\u6709\u6bd2\u6027\u7684\uff0c\u986f\u793a\u4e86\u5ddd\u9673\u76ae\u7d20\u7684\u6548\u7528\u662f\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u3002\u9032\u4e00\u6b65\u7684\u89c0\u5bdf\u767c\u73fe\uff0c\u5ddd\u9673\u76ae\u7d20\u53ef\u4ee5\u8b93\u764c\u7d30\u80de\u505c\u7559\u5728\u7d30\u80de\u9031\u671f\u7684G1\u968e\u6bb5\u800c\u4e0d\u7e7c\u7e8c\u9032\u884c\u5206\u88c2\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u7531\u65bc\u904e\u53bb\u984f\u6559\u6388\u5be6\u9a57\u5ba4\u66fe\u767c\u73fe\u5ddd\u9673\u76ae\u7d20\u53ef\u4ee5\u523a\u6fc0\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u7d30\u80de\u682a\u7684\u5206\u5316\uff0c\u800c\u7576\u764c\u7d30\u80de\u9032\u884c\u5206\u5316\u6642\uff0c\u4fbf\u610f\u5473\u8457\u764c\u7d30\u80de\u7684\u60e1\u6027\u5ea6\u964d\u4f4e\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u5718\u968a\u6c7a\u5b9a\u8981\u770b\u770b\u5ddd\u9673\u76ae\u7d20\u5c0d\u65bc\u6162\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\u662f\u5426\u6709\u985e\u4f3c\u7684\u6548\u679c\u3002\u540c\u6a23\u662f\u5728K562\u9019\u500b\u7d30\u80de\u682a\u4e0a\uff0c\u53ea\u9700\u898140\u621680\u5fae\u83ab\u8033\u7684\u5ddd\u9673\u76ae\u7d20\uff0c\u4fbf\u53ef\u4f7fK562\u7d30\u80de\u671d\u5411\u8840\u5c0f\u677f\u7684\u65b9\u5411\u5206\u5316\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u65e2\u7136\u5ddd\u9673\u76ae\u7d20\u53ef\u4ee5\u6291\u5236\u764c\u7d30\u80de\u7684\u6d3b\u6027\u3001\u4f7f\u764c\u7d30\u80de\u4e0d\u7e7c\u7e8c\u9032\u884c\u5206\u88c2\u3001\u751a\u81f3\u958b\u59cb\u9032\u884c\u5206\u5316\uff0c\u90a3\u9ebc\u5b83\u662f\u5426\u53ef\u4ee5\u8207\u76ee\u524d\u73fe\u884c\u7684\u5316\u7642\u85e5\u7269\uff08\u5982\uff1a\u57fa\u5229\u514b\uff09\u5408\u4f75\u4f7f\u7528\uff0c\u8b93\u5316\u7642\u85e5\u7269\u7684\u9700\u6c42\u6e1b\u5c11\u5462\uff1f\u984f\u6559\u6388\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u55ae\u7368\u4f7f\u75280.2\u5fae\u83ab\u8033\u7684\u57fa\u5229\u514b\u8207\u55ae\u7368\u4f7f\u752840\u5fae\u83ab\u8033\u7684\u5ddd\u9673\u76ae\u7d20\uff0c\u5c0d\u65bc\u764c\u7d30\u80de\u6d3b\u6027\u7684\u6291\u5236\u6548\u679c\u662f\u76f8\u540c\u7684\uff1b\u4f46\u82e5\u5c070.2\u5fae\u83ab\u8033\u7684\u57fa\u5229\u514b\u820740\u5fae\u83ab\u8033\u7684\u5ddd\u9673\u76ae\u7d20\u5408\u4f75\u4f7f\u7528\uff0c\u764c\u7d30\u80de\u6d3b\u6027\u4fbf\u5927\u5927\u5730\u4e0b\u964d\u3002\u9019\u610f\u5473\u8457\u5982\u80fd\u5c07\u5ddd\u9673\u76ae\u7d20\u8207\u57fa\u5229\u514b\u5408\u4f75\u4f7f\u7528\uff0c\u9700\u8981\u7684\u57fa\u5229\u514b\u7684\u91cf\u53ef\u4ee5\u518d\u964d\u4f4e\uff0c\u5982\u6b64\u4e00\u4f86\u4fbf\u53ef\u6e1b\u4f4e\u60a3\u8005\u5c0d\u57fa\u5229\u514b\u7522\u751f\u6297\u6027\u7684\u6a5f\u7387\u3002<\/span><\/p>\n<p class=\"p2\" style=\"text-align: justify;\"><span class=\"s1\">\u672a\u4f86\u662f\u5426\u80fd\u5920\u5c07\u5ddd\u9673\u76ae\u7d20\u61c9\u7528\u5728\u81e8\u5e8a\u5462\uff1f\u7531\u65bc\u5ddd\u9673\u76ae\u7d20\u7684\u6c34\u6eb6\u6027\u4e0d\u4f73\uff0c\u5982\u8981\u61c9\u7528\u5728\u81e8\u5e8a\u4e0a\u53ef\u80fd\u5f97\u5148\u5c07\u5ddd\u9673\u76ae\u7d20\u9032\u884c\u4e00\u4e9b\u7d50\u69cb\u4e0a\u7684\u4fee\u98fe\u3002\u7121\u8ad6\u5982\u4f55\uff0c\u984f\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u70ba\u764c\u75c7\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u4e00\u500b\u65b0\u65b9\u5411\uff0c\u4e5f\u671f\u76fc\u672a\u4f86\u53ef\u4ee5\u807d\u5230\u5ddd\u9673\u76ae\u7d20\u66f4\u591a\u7684\u597d\u6d88\u606f\u5594\uff01<\/span><\/p>\n<p class=\"p4\" style=\"text-align: justify;\"><span class=\"s1\">\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n<p class=\"p4\" style=\"text-align: justify;\"><span class=\"s1\">J.-H. Yen et. al. 2020. Nobiletin promotes megakaryocytic differentiation through the MAPK\/ERK-dependent EGR1 expression and exerts anti-leukemic effect in human chronic myeloid leukemia (CML) K562 cells. Cells. doi:10.3390\/cells9040877<\/span><\/p>\n<p><a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-5059 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9030-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-5060 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9033-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a> <a href=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-5061 size-full\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2020\/04\/DSC9035-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\uff1a\u8449\u7da0\u8212\uff0f\u5716\uff1a\u6797\u54f2\u5148 \u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u984f\u745e\u9d3b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5059,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-5058","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/5058","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5058"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/5058\/revisions"}],"predecessor-version":[{"id":12154,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/5058\/revisions\/12154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/5059"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5058"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5058"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5058"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}