{"id":19618,"date":"2025-06-27T16:13:00","date_gmt":"2025-06-27T08:13:00","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=19618"},"modified":"2025-06-27T16:13:00","modified_gmt":"2025-06-27T08:13:00","slug":"%e9%81%8b%e5%8b%95%e7%a5%9e%e7%b6%93%e5%85%83%e7%96%be%e7%97%85%e7%9a%84%e6%a9%9f%e5%88%b6%e5%92%8c%e6%b2%bb%e7%99%82%e6%96%b9%e6%b3%95%ef%bc%9asma%e5%92%8cals-%e7%be%8e%e5%9c%8b%e5%8d%97%e5%8a%a0","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=19618","title":{"rendered":"\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5\uff1aSMA\u548cALS \u7f8e\u570b\u5357\u52a0\u5927\u751f\u7269\u79d1\u5b78\u7cfb\u795e\u7d93\u751f\u7269\u5b78\u7d44\u67ef\u7c21\u8a55\u6559\u6388(Chien-Ping KO, PhD)\u849e\u81e8\u6148\u6fdf\u5927\u5b78\u5206\u4eab"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">114<\/span><span class=\"s2\">\u5e74<\/span><span class=\"s1\">4<\/span><span class=\"s2\">\u6708<\/span><span class=\"s1\">16<\/span><span class=\"s2\">\u65e5\u6148\u6fdf\u5927\u5b78\u7814\u7a76\u767c\u5c55\u8655\u5b78\u8853\u7814\u7a76\u7d44\u8209\u8fa6\u5c08\u984c\u6f14\u8b1b\uff0c\u672c\u6b21\u6f14\u8b1b\u9080\u8acb\u7f8e\u570b\u5357\u52a0\u5927\u751f\u7269\u79d1\u5b78\u7cfb\u795e\u7d93\u751f\u7269\u5b78\u7d44\u67ef\u7c21\u8a55\u6559\u6388<\/span><span class=\"s3\">(Chien-Ping KO, PhD)<\/span><span class=\"s2\">\uff0c\u900f\u904e\u6f14\u8b1b\u4e3b\u984c\u300c\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236\u548c\u6cbb\u7642\u65b9\u6cd5\uff1a<\/span><span class=\"s3\">SMA<\/span><span class=\"s2\">\u548c<\/span><span class=\"s3\">ALS<\/span><span class=\"s2\">\u300d\uff0c\u53ef\u6709\u6548\u63d0\u5347\u8207\u6703\u8005\u5c0d\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7\uff08<\/span><span class=\"s3\">SMA<\/span><span class=\"s2\">\uff09\u53ca\u808c\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08<\/span><span class=\"s3\">ALS<\/span><span class=\"s2\">\uff09\u7b49\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u4e4b\u75c5\u7406\u6a5f\u8f49\u8207\u6700\u65b0\u6cbb\u7642\u9032\u5c55\u7684\u7406\u89e3\u3002\u6d3b\u52d5\u7d50\u5408\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u89c0\u9ede\uff0c\u4e0d\u50c5\u4fc3\u9032\u91ab\u7642\u8207\u7814\u7a76\u4eba\u54e1\u4e4b\u9593\u7684\u77e5\u8b58\u4ea4\u6d41\uff0c\u4e5f\u5f37\u5316\u8de8\u9818\u57df\u5408\u4f5c\u5951\u6a5f\u3002\u6b64\u5916\uff0c\u85c9\u7531\u5c08\u5bb6\u6df1\u5165\u6dfa\u51fa\u7684\u5206\u4eab\uff0c\u6709\u52a9\u65bc\u63d0\u9ad8\u5c0d\u7f55\u898b\u795e\u7d93\u75be\u75c5\u7684\u91cd\u8996\uff0c\u9032\u800c\u63a8\u52d5\u672a\u4f86\u5728\u8a3a\u65b7\u6280\u8853\u3001\u6cbb\u7642\u7b56\u7565\u53ca\u75c5\u60a3\u7167\u8b77\u4e0a\u7684\u767c\u5c55\u8207\u5275\u65b0\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s2\">\u8b1b\u5e2b\u4ee5\u8c50\u5bcc\u7684\u7814\u7a76\u6210\u679c\uff0c\u4ecb\u7d39\u810a\u9ad3\u808c\u8089\u840e\u7e2e\u75c7\uff08<\/span><span class=\"s1\">SMA<\/span><span class=\"s2\">\uff09\u8207\u808c\u840e\u7e2e\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7<\/span><span class=\"s1\">,<\/span><span class=\"s2\">\u808c\u840e\u7e2e\u5074\u7d22\u786c\u5316\u75c7<\/span><span class=\"s1\">,<\/span><span class=\"s2\">\u6f38\u51cd\u4eba\u75c7\uff08<\/span><span class=\"s1\">ALS<\/span><span class=\"s2\">\uff09\u5169\u7a2e\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u75c5\u7406\u6a5f\u5236\u53ca\u6700\u65b0\u6cbb\u7642\u9032\u5c55\u3002\u9996\u5148\u8aaa\u660e<\/span><span class=\"s1\"> SMA <\/span><span class=\"s2\">\u662f\u4e00\u7a2e\u67d3\u8272\u4f53\u96b1\u6027\u907a\u50b3\u75be\u75c5\uff0c\u662f\u5b30\u5152\u6b7b\u4ea1\u6700\u5e38\u898b\u7684\u55ae\u57fa\u56e0\u539f\u56e0<\/span><span class=\"s1\">(<\/span><span class=\"s2\">\u7f55\u898b\u75be\u75c5<\/span><span class=\"s1\">)<\/span><span class=\"s2\">\uff0c\u5728\u7f8e\u570b\u6709<\/span><span class=\"s1\">25,000<\/span><span class=\"s2\">\u540d\u60a3\u8005\u3001\u5728\u53f0\u7063\u7d04\u6709<\/span><span class=\"s1\">400<\/span><span class=\"s2\">\u540d\u60a3\u8005\uff0c\u4e26\u9032\u4e00\u6b65\u63a2\u8a0e<\/span><span class=\"s1\"> SMN2 <\/span><span class=\"s2\">\u57fa\u56e0\u7684\u526a\u63a5\u7570\u5e38\u5c0d\u75c5\u60c5\u56b4\u91cd\u5ea6\u7684\u5f71\u97ff\uff0c\u5728<\/span><span class=\"s3\">ALS<\/span><span class=\"s2\">\u90e8\u5206\uff0c\u8b1b\u5e2b\u805a\u7126\u65bc<\/span><span class=\"s3\">UNC13A<\/span><span class=\"s2\">\u57fa\u56e0\u932f\u8aa4\u526a\u63a5\u8207<\/span><span class=\"s3\">TDP-43<\/span><span class=\"s2\">\u86cb\u767d\u7570\u5e38\u7684\u95dc\u806f\uff0c\u4e26\u5c55\u793a\u4e86\u7531<\/span><span class=\"s3\">AcuraStem<\/span><span class=\"s2\">\u5718\u968a\u958b\u767c\u4e4b<\/span><span class=\"s3\">UNC13A<\/span><span class=\"s2\">\u53cd\u7fa9\u5be1\u6838\u82f7\u9178\uff08<\/span><span class=\"s3\">ASO<\/span><span class=\"s2\">\uff09\u7684\u7814\u7a76\u6210\u679c\u3002\u8a72\u7642\u6cd5\u53ef\u6709\u6548\u963b\u6b62<\/span><span class=\"s3\">UNC13A<\/span><span class=\"s2\">\u7684\u96b1\u6027\u5916\u986f\u5b50\u932f\u8aa4\u526a\u63a5\uff0c\u6062\u5fa9\u86cb\u767d\u8868\u9054\u8207\u7a81\u89f8\u529f\u80fd\uff0c\u5c55\u73fe\u672a\u4f86\u4f5c\u70ba<\/span><span class=\"s3\"> ALS <\/span><span class=\"s2\">\u75be\u75c5\u6539\u8b8a\u6cbb\u7642\uff08<\/span><span class=\"s3\">disease-modifying therapy<\/span><span class=\"s2\">\uff09\u4e4b\u6f5b\u529b\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s2\">\u672c\u6b21\u6f14\u8b1b\u5167\u5bb9\u8c50\u5bcc\uff0c\u6a6b\u8de8\u907a\u50b3\u5b78\u3001\u795e\u7d93\u751f\u7269\u5b78\u3001\u85e5\u7269\u958b\u767c\u8207\u81e8\u5e8a\u7814\u7a76\u7b49\u591a\u500b\u5c64\u9762\uff0c\u5438\u5f15\u8a31\u591a\u6559\u5e2b\u8207\u5b78\u751f\u53c3\u52a0\uff0c\u6f14\u8b1b\u7d50\u675f\u5f8c\u5e2b\u751f\u5011\u4e5f\u5f88\u8e34\u8e8d\u56de\u994b\u8207\u63d0\u554f\u7c21\u5831\u5167\u5bb9\uff0c\u671f\u5f85\u85c9\u7531\u6b64\u6b21\u6f14\u8b1b\u672c\u6821\u5e2b\u751f\u8207\u8b1b\u5e2b\u5b78\u8853\u5408\u4f5c\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19619\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71.jpg\" alt=\"\" width=\"1024\" height=\"673\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71-300x197.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71-768x505.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71-730x480.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u53c3\u8207\u5e2b\u751f\u8207\u8b1b\u5e2b\u5408\u5f71-435x286.jpg 435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19620\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u6559\u5e2b\u56de\u994b\u8207\u63d0\u554f-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19621\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6a5f\u5236-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19622\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u8207\u6703\u8005\u805a\u7cbe\u6703\u795e\u8046\u807d-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19623\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-19624\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/06\/\u5b78\u751f\u56de\u994b\u8207\u63d0\u554f2-1-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>114\u5e744\u670816\u65e5\u6148\u6fdf\u5927\u5b78\u7814\u7a76\u767c\u5c55\u8655\u5b78\u8853\u7814\u7a76\u7d44\u8209\u8fa6\u5c08\u984c\u6f14\u8b1b\uff0c [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":19621,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-19618","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/19618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19618"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/19618\/revisions"}],"predecessor-version":[{"id":19625,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/19618\/revisions\/19625"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/19621"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}