{"id":18944,"date":"2025-05-14T16:51:34","date_gmt":"2025-05-14T08:51:34","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=18944"},"modified":"2025-05-14T16:51:34","modified_gmt":"2025-05-14T08:51:34","slug":"%e6%85%88%e5%a4%a7%e9%86%ab%e5%ad%b8%e9%99%a2%e3%80%8a%e5%a4%a7%e5%b8%ab%e5%82%b3%e7%bf%92%e3%80%8b%e9%82%80%e8%ab%8b%e4%b8%ad%e7%a0%94%e9%99%a2%e5%8a%89%e6%89%b6%e6%9d%b1%e9%99%a2%e5%a3%ab%e8%92%9e-2","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=18944","title":{"rendered":"\u6148\u5927\u91ab\u5b78\u9662\u300a\u5927\u5e2b\u50b3\u7fd2\u300b\u9080\u8acb\u4e2d\u7814\u9662\u5289\u6276\u6771\u9662\u58eb\u849e\u81e8\u5230\u6821\u6307\u5c0e\u5e2b\u751f"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u70ba\u4fc3\u9032\u8de8\u9818\u57df\u5b78\u8853\u4ea4\u6d41\uff0c\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u9662\u65bc<\/span><span class=\"s2\">114<\/span><span class=\"s1\">\u5e74<\/span><span class=\"s2\">4<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">24<\/span><span class=\"s1\">\u65e5\u8209\u8fa6\u300a\u5927\u5e2b\u50b3\u7fd2\u300b\u7cfb\u5217\u6d3b\u52d5\uff0c\u69ae\u5e78\u9080\u8acb\u4e2d\u592e\u7814\u7a76\u9662<\/span><span class=\"s3\">\u5289\u6276\u6771<\/span><span class=\"s1\">\u9662\u58eb\u849e\u81e8\u6307\u5c0e\u3002<\/span><span class=\"s3\">\u5289<\/span><span class=\"s1\">\u9662\u58eb\u9577\u671f\u81f4\u529b\u65bc\u63a8\u52d5\u5b78\u8853\u4ea4\u6d41\u8207\u7814\u7a76\u7d93\u9a57\u50b3\u627f\uff0c\u591a\u6b21\u9020\u8a2a\u672c\u6821\uff0c\u7a4d\u6975\u5354\u52a9\u91ab\u5b78\u9662\u5e2b\u751f\u53ca\u5404\u7cfb\u6240\u7684\u7814\u7a76\u767c\u5c55\uff0c\u4e26\u6301\u7e8c\u63d0\u5347\u6148\u6fdf\u5927\u5b78\u65bc\u751f\u91ab\u7814\u7a76\u8207\u8f49\u8b6f\u91ab\u5b78\u9818\u57df\u7684\u80fd\u91cf\u8207\u570b\u969b\u80fd\u898b\u5ea6\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u5728\u4e2d\u5348\u7684\u6f14\u8b1b\u4e2d\uff0c<\/span><span class=\"s3\">\u5289\u6276\u6771<\/span><span class=\"s1\">\u9662\u58eb\u4ee5\u300c<\/span><span class=\"s2\">Functional Glycomics in Health and Disease<\/span><span class=\"s1\">\u300d\u70ba\u984c\uff0c\u6df1\u5165\u89e3\u6790\u300c\u529f\u80fd\u6027\u7cd6\u7d44\u5b78\u300d\u65bc\u5065\u5eb7\u8207\u75be\u75c5\u4e2d\u7684\u95dc\u9375\u89d2\u8272\uff0c\u7279\u5225\u805a\u7126\u65bc\u514d\u75ab\u7403\u86cb\u767d<\/span><span class=\"s2\">G<\/span><span class=\"s1\">\uff08<\/span><span class=\"s2\">IgG<\/span><span class=\"s1\">\uff09\u7684\u7cd6\u57fa\u5316\u8b8a\u5316\u5c0d\u514d\u75ab\u7cfb\u7d71\u529f\u80fd\u7684\u6df1\u9060\u5f71\u97ff\u3002\u6f14\u8b1b\u6307\u51fa\uff0c<\/span><span class=\"s2\">IgG<\/span><span class=\"s1\">\u7684<\/span><span class=\"s2\">N-<\/span><span class=\"s1\">\u7cd6\u57fa\u5316\u53d7\u907a\u50b3\u3001\u8868\u89c0\u907a\u50b3\u8207\u74b0\u5883\u56e0\u5b50\u8abf\u63a7\uff0c\u4e26\u6d89\u53ca\u591a\u7a2e\u9175\u7d20\u8abf\u7bc0\uff0c\u5982\u5ca9\u85fb\u7cd6\u5316\uff08<\/span><span class=\"s2\">Fucosylation<\/span><span class=\"s1\">\uff09\u3001\u96d9\u5206\u652f\u7cd6\u57fa\u5316\uff08<\/span><span class=\"s2\">Bisecting<\/span><span class=\"s1\">\uff09\u3001\u553e\u6db2\u9178\u5316\uff08<\/span><span class=\"s2\">Sialylation<\/span><span class=\"s1\">\uff09\u53ca\u534a\u4e73\u7cd6\u5316\uff08<\/span><span class=\"s2\">Galactosylation<\/span><span class=\"s1\">\uff09\u3002\u4f8b\u5982\uff0c\u7f3a\u4e4f\u6838\u5fc3\u5ca9\u85fb\u7cd6\u7684<\/span><span class=\"s2\">IgG1<\/span><span class=\"s1\">\u53ef\u589e\u5f37\u6297\u9ad4\u4f9d\u8cf4\u6027\u7d30\u80de\u6bd2\u6027\uff08<\/span><span class=\"s2\">ADCC<\/span><span class=\"s1\">\uff09\uff0c\u6709\u52a9\u65bc\u63d0\u5347\u816b\u7624\u7d30\u80de\u7684\u6e05\u9664\u6548\u679c\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s1\">\u6f14\u8b1b\u4e2d\u4ea6\u4ecb\u7d39\u9ad8\u901a\u91cf\u81ea\u52d5\u5316<\/span><span class=\"s2\">IgG<\/span><span class=\"s1\">\u7cd6\u86cb\u767d\u5206\u6790\u5e73\u53f0\uff0c\u4ee5\u53ca\u5982\u4f55\u900f\u904e<\/span><span class=\"s2\">IgG<\/span><span class=\"s1\">\u7cd6\u57fa\u5316\u6a21\u5f0f\u4f5c\u70ba\u75be\u75c5\u8a3a\u65b7\u3001\u9810\u5f8c\u8207\u751f\u6d3b\u65b9\u5f0f\u6307\u6a19\uff08\u5982\u7cd6\u57fa\u5e74\u9f61\uff09\u7684\u751f\u7269\u6a19\u8a8c\u3002\u529f\u80fd\u6027\u7cd6\u7d44\u5b78\u4e5f\u6db5\u84cb\u7cd6\u86cb\u767d\u7d50\u5408\u86cb\u767d\u7684\u7814\u7a76\uff0c\u5305\u62ec\u9078\u51dd\u7d20\uff08<\/span><span class=\"s2\">Selectins<\/span><span class=\"s1\">\uff09\u3001\u553e\u6db2\u9178\u53d7\u9ad4\uff08<\/span><span class=\"s2\">Siglecs<\/span><span class=\"s1\">\uff09\u8207\u534a\u4e73\u51dd\u7d20\uff08<\/span><span class=\"s2\">Galectins<\/span><span class=\"s1\">\uff09\uff0c\u5176\u5728\u708e\u75c7\u3001\u816b\u7624\u514d\u75ab\u8207\u7e96\u7dad\u5316\u75be\u75c5\u4e2d\u7684\u529f\u80fd\u8207\u61c9\u7528\u6b63\u9010\u6b65\u88ab\u63ed\u793a\u3002\u90e8\u5206\u7cd6\u86cb\u767d\u9776\u9ede\u7684\u55ae\u514b\u9686\u6297\u9ad4\u8207\u6291\u5236\u5291\uff0c\u5982<\/span><span class=\"s2\">Crizanlizumab<\/span><span class=\"s1\">\u3001<\/span><span class=\"s2\">Lirentelimab<\/span><span class=\"s1\">\u8207<\/span><span class=\"s2\">TD139<\/span><span class=\"s1\">\uff0c\u5df2\u9032\u5165\u81e8\u5e8a\u61c9\u7528\uff0c\u5c55\u73fe\u7cd6\u7d44\u5b78\u7814\u7a76\u7684\u9ad8\u5ea6\u81e8\u5e8a\u8f49\u8b6f\u6f5b\u529b\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u4e0b\u5348\u5834\u6b21\u5247\u7531\u4e09\u4f4d\u7814\u7a76\u8005\u9032\u884c\u5b78\u8853\u5206\u4eab\uff0c\u6db5\u84cb\u816b\u7624\u5e79\u7d30\u80de\u9776\u5411\u6cbb\u7642\u3001\u5e79\u7d30\u80de\u65bc\u795e\u7d93\u75be\u75c5\u7684\u61c9\u7528\uff0c\u4ee5\u53ca\u5375\u5de2\u764c\u5fae\u74b0\u5883\u7814\u7a76\u4e09\u5927\u4e3b\u984c\uff0c\u5c55\u73fe\u672c\u6821\u7814\u7a76\u5718\u968a\u65bc\u764c\u75c7\u8207\u795e\u7d93\u91ab\u5b78\u9818\u57df\u7684\u591a\u5143\u63a2\u7d22\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s3\">\u5289\u975c\u5b89<\/span><span class=\"s1\">\u535a\u58eb\u767c\u8868\u300c\u60e1\u6027\u816b\u7624\u5e79\u7d30\u80de\u9776\u5411\u7684\u5916\u6ccc\u9ad4\u6297\u9ad4\u7814\u7a76\u300d\uff0c\u4ee5\u8166\u7624\u5e79\u7d30\u80de\u70ba\u6a21\u578b\uff0c\u63a2\u8a0e\u5176\u5916\u6ccc\u9ad4\u6240\u651c\u5e36\u7684\u6a19\u8a18\u7269\uff0c\u4e26\u958b\u767c\u5177\u9776\u5411\u80fd\u529b\u7684\u55ae\u682a\u6297\u9ad4\u9032\u884c\u6291\u5236\u3002\u521d\u6b65\u7814\u7a76\u6210\u679c\u986f\u793a\u6b64\u7b56\u7565\u53ef\u6709\u6548\u6e1b\u7de9\u816b\u7624\u5e79\u7d30\u80de\u751f\u9577\uff0c\u4e26\u7d50\u5408<\/span><span class=\"s2\">CRISPR\/Cas9<\/span><span class=\"s1\">\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\u9032\u884c\u529f\u80fd\u9a57\u8b49\uff0c\u70ba\u7cbe\u6e96\u816b\u7624\u6cbb\u7642\u958b\u5275\u65b0\u65b9\u5411\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s3\">\u5f35\u5609\u4f51<\/span><span class=\"s1\">\u6280\u8853\u9577\u5247\u4ee5\u300c\u5e79\u7d30\u80de\u6cbb\u7642\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u7684\u767c\u5c55\u300d\u70ba\u984c\uff0c\u8aaa\u660e\u5176\u7814\u7a76\u5718\u968a\u4ee5\u75c5\u60a3\u4f86\u6e90\u7684\u8a98\u5c0e\u591a\u6f5b\u80fd\u5e79\u7d30\u80de\uff08<\/span><span class=\"s2\">iPSC<\/span><span class=\"s1\">\uff09\u70ba\u57fa\u790e\uff0c\u958b\u767c\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u7d30\u80de\u6cbb\u7642\u7b56\u7565\u3002\u85c9\u7531<\/span><span class=\"s2\">N-BP<\/span><span class=\"s1\">\u4ecb\u5165\u986f\u8457\u63d0\u5347\u591a\u5df4\u80fa\u795e\u7d93\u5143\u7684\u5206\u5316\u6548\u7387\u8207\u795e\u7d93\u7a81\u89f8\u5f62\u6210\uff0c\u4e26\u65bc\u52d5\u7269\u5be6\u9a57\u4e2d\u89c0\u5bdf\u5230\u904b\u52d5\u529f\u80fd\u7684\u986f\u8457\u6539\u5584\uff0c\u5c55\u73fe\u5e79\u7d30\u80de\u65bc\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\u6cbb\u7642\u7684\u6f5b\u529b\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s3\">\u9ec3\u7384\u821c<\/span><span class=\"s1\">\u535a\u58eb\u5247\u5206\u4eab\u300c\u5375\u6ce1\u6db2\u751f\u9577\u56e0\u5b50\u5c0d\u5375\u5de2\u764c\u767c\u5c55\u7684\u5f71\u97ff\u300d\uff0c\u805a\u7126\u65bc\u6392\u5375\u671f\u9593\u91cb\u653e\u7684\u5375\u6ce1\u6db2\u56e0\u5b50\u5982\u4f55\u6539\u8b8a\u5375\u5de2\u764c\u7d30\u80de\u7684\u5fae\u74b0\u5883\u3002\u7814\u7a76\u6df1\u5165\u63a2\u8a0e<\/span><span class=\"s2\">IGF<\/span><span class=\"s1\">\u8207<\/span><span class=\"s2\">HGF<\/span><span class=\"s1\">\u8a0a\u865f\u8ef8\u53ca\u5176\u8a98\u767c\u7684\u514d\u75ab\u53cd\u61c9\uff08\u5982<\/span><span class=\"s2\">NETosis<\/span><span class=\"s1\">\uff09\uff0c\u63ed\u793a\u5176\u65bc\u816b\u7624\u7d30\u80de\u8f49\u5316\u8207\u8179\u819c\u64f4\u6563\u904e\u7a0b\u4e2d\u7684\u95dc\u9375\u89d2\u8272\uff0c\u4e26\u63d0\u51fa\u53ef\u671b\u5ef6\u4f38\u81f3\u5176\u4ed6\u764c\u75c7\u985e\u578b\u4e4b\u7814\u7a76\u69cb\u60f3\u3002<\/span><\/p>\n<p class=\"p5\"><span class=\"s1\">\u672c\u6b21\u300c\u5927\u5e2b\u50b3\u7fd2\u300d\u7cfb\u5217\u6d3b\u52d5\u4e0d\u50c5\u6df1\u5316\u4e86\u5e2b\u751f\u5c0d\u7cd6\u7d44\u5b78\u8207\u7cbe\u6e96\u91ab\u7642\u7684\u8a8d\u8b58\uff0c\u4e5f\u5c55\u73fe\u672c\u6821\u7814\u7a76\u5718\u968a\u5728\u764c\u75c7\u8207\u795e\u7d93\u91ab\u5b78\u9818\u57df\u7684\u5275\u65b0\u80fd\u91cf\u3002\u672a\u4f86\u91ab\u5b78\u9662\u5c07\u6301\u7e8c\u63a8\u52d5\u8de8\u9818\u57df\u6574\u5408\u8207\u570b\u969b\u5408\u4f5c\uff0c\u4fc3\u9032\u9ad8\u968e\u7814\u7a76\u6210\u679c\u7684\u81e8\u5e8a\u8f49\u8b6f\uff0c\u958b\u5275\u66f4\u5177\u5f71\u97ff\u529b\u7684\u91ab\u5b78\u65b0\u7bc7\u7ae0\u3002\uff08\u5716<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u6587\uff1a\u91ab\u5b78\u9662\uff09<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18945\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u4e01\u5927\u6e05\u526f\u9662\u9577\u81f4\u8a5e-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-18946\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/05\/\u5c39\u7acb\u9298\u526f\u9662\u9577\u4ee3\u8868\u81f4\u8d08\u611f\u8b1d\u72c0-435x290.jpg 435w, 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