{"id":17882,"date":"2025-02-06T09:56:08","date_gmt":"2025-02-06T01:56:08","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=17882"},"modified":"2025-02-06T09:56:08","modified_gmt":"2025-02-06T01:56:08","slug":"%e6%85%88%e6%bf%9f%e5%a4%a7%e5%ad%b8%e9%86%ab%e5%b7%a5%e7%b3%bb%e8%88%89%e8%be%a6%e7%b5%b1%e8%a8%88%e5%9f%ba%e5%9b%a0%e9%ab%94%e8%81%af%e5%90%88%e5%b7%a5%e4%bd%9c%e5%9d%8a","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=17882","title":{"rendered":"\u6148\u6fdf\u5927\u5b78\u91ab\u5de5\u7cfb\u8209\u8fa6\u7d71\u8a08\u57fa\u56e0\u9ad4\u806f\u5408\u5de5\u4f5c\u574a"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u6587<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78\u751f\u7269\u91ab\u5b78\u66a8\u5de5\u7a0b\u7cfb<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u751f\u7269\u91ab\u5b78\u66a8\u5de5\u7a0b\u5b78\u7cfb<\/span><span class=\"s2\">1<\/span><span class=\"s1\">\u6708<\/span><span class=\"s2\">6<\/span><span class=\"s1\">\u65e5\u81f3<\/span><span class=\"s2\">10<\/span><span class=\"s1\">\u65e5\u8209\u8fa6\u70ba\u671f\u4e94\u5929\u7684\u300c<\/span><span class=\"s2\">TCU-Exeter University<\/span><span class=\"s1\">\u7d71\u8a08\u57fa\u56e0\u9ad4\u806f\u5408\u5de5\u4f5c\u574a\u300d\uff0c\u7279\u5225\u9080\u8acb\u82f1\u570b\u827e\u5e0c\u7279\u5927\u5b78\uff08<\/span><span class=\"s2\">Exeter University<\/span><span class=\"s1\">\uff09\u5065\u5eb7\u6578\u64da\u79d1\u5b78\u5c08\u5bb6<\/span><span class=\"s2\">Prof. Harry Green<\/span><span class=\"s1\">\u849e\u6821\u5206\u4eab\u5176\u5728<\/span><span class=\"s2\">UK Biobank<\/span><span class=\"s1\">\u8cc7\u6599\u5eab\u7684\u61c9\u7528\u7d93\u9a57\u8207\u76f8\u95dc\u7814\u7a76\u3002\u6d3b\u52d5\u5167\u5bb9\u8c50\u5bcc\u800c\u6df1\u5165\uff0c\u7d50\u5408\u7406\u8ad6\u8207\u5be6\u52d9\uff0c\u6db5\u84cb\u57fa\u790e\u77e5\u8b58\uff0c\u66f4\u8457\u91cd\u65bc\u5be6\u969b\u61c9\u7528\u548c\u524d\u6cbf\u6280\u8853\u3002<\/span><span class=\"s2\">Prof. Herry Green<\/span><span class=\"s1\">\u662f\u4e00\u4f4d\u5065\u5eb7\u6578\u64da\u79d1\u5b78\u5c08\u5bb6\uff0c\u64c1\u6709\u6578\u5b78\u5efa\u6a21\u80cc\u666f\uff0c\u7814\u7a76\u5c08\u6ce8\u65bc\u61c9\u7528\u6578\u5b78\u548c\u7d71\u8a08\u6a21\u578b\u4f86\u89e3\u6790\u4eba\u9ad4\u751f\u7406\u5b78\uff0c\u4e26\u5229\u7528\u5927\u578b\u6578\u64da\u8cc7\u6e90\u9810\u6e2c\u7d50\u679c\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u5de5\u4f5c\u574a\u7684\u9996\u65e5\u8ab2\u7a0b\u5f9e<\/span><span class=\"s2\">DNA<\/span><span class=\"s1\">\u7d50\u69cb\u8207\u4e2d\u5fc3\u6cd5\u5247\u7b49\u57fa\u790e\u6982\u5ff5\u958b\u59cb\uff0c\u9010\u6b65\u6df1\u5165\u5230\u73fe\u4ee3\u8907\u96dc\u6027\u72c0\u7814\u7a76\uff0c\u5167\u5bb9\u6db5\u84cb\u4e0d\u540c\u57fa\u56e0\u7d44\u6e2c\u5e8f\u6280\u8853\u7684\u6bd4\u8f03\u53ca\u672a\u4f86\u907a\u50b3\u5b78\u7814\u7a76\u65b9\u5411\u7684\u8da8\u52e2\u3002\u5b78\u54e1\u5b78\u7fd2\u4e86\u5168\u57fa\u56e0\u7d44\u95dc\u806f\u5206\u6790\uff08<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\uff09\u3001\u8868\u89c0\u907a\u50b3\u5b78\u7b49\u61c9\u7528\u77e5\u8b58\uff0c\u4e26\u5728\u8b1b\u5e2b\u6307\u5c0e\u4e0b\u719f\u6089<\/span><span class=\"s2\">PLINK<\/span><span class=\"s1\">\u8edf\u9ad4\u7684\u57fa\u672c\u64cd\u4f5c\uff0c\u70ba\u5f8c\u7e8c\u7684\u5be6\u4f5c\u5960\u5b9a\u57fa\u790e\u3002\u7b2c\u4e8c\u5929\u7684\u8ab2\u7a0b\u805a\u7126\u65bc<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\u7684\u5be6\u969b\u64cd\u4f5c\u8207\u7d50\u679c\u89e3\u8b80\uff0c\u5305\u62ec\u8868\u578b\u6578\u64da\u7684\u6e96\u5099\u3001\u5728<\/span><span class=\"s2\">PLINK<\/span><span class=\"s1\">\u4e2d\u57f7\u884c<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\uff0c\u4ee5\u53ca\u5982\u4f55\u4f7f\u7528<\/span><span class=\"s2\">R<\/span><span class=\"s1\">\u8a9e\u8a00\u4f86\u53ef\u8996\u5316\u7d50\u679c\uff0c\u5305\u62ec\u66fc\u54c8\u9813\u5716\u548c<\/span><span class=\"s2\">QQ<\/span><span class=\"s1\">\u5716\u7684\u7e6a\u88fd\u3002\u5b78\u54e1\u6df1\u523b\u7406\u89e3<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\u5728\u75be\u75c5\u76f8\u95dc\u57fa\u56e0\u767c\u6398\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u540c\u6642\u4e5f\u8a8d\u8b58\u5230\u4eba\u53e3\u7d50\u69cb\u5c0d<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\u7d50\u679c\u7684\u5f71\u97ff\uff0c\u9019\u8b93\u5b78\u54e1\u610f\u8b58\u5230\u5728\u5be6\u969b\u7814\u7a76\u4e2d\u63a7\u5236\u6df7\u96dc\u56e0\u7d20\u7684\u91cd\u8981\u6027\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u7b2c\u4e09\u5929\u8ab2\u7a0b\u805a\u7126\u907a\u50b3\u98a8\u96aa\u8a55\u5206\uff08<\/span><span class=\"s2\">GRS<\/span><span class=\"s1\">\uff09\u7684\u8a08\u7b97\u548c\u89e3\u91cb\uff0c\u5b78\u54e1\u5b78\u7fd2\u5982\u4f55\u4f7f\u7528<\/span><span class=\"s2\">PLINK<\/span><span class=\"s1\">\u8a08\u7b97<\/span><span class=\"s2\">GRS<\/span><span class=\"s1\">\uff0c\u4e26\u5728<\/span><span class=\"s2\">R<\/span><span class=\"s1\">\u4e2d\u9032\u884c\u7d71\u8a08\u5206\u6790\uff0c\u9084\u5b78\u7fd2\u4e86\u5982\u4f55\u69cb\u5efa\u6574\u5408\u98a8\u96aa\u6a21\u578b\uff0c\u5c07<\/span><span class=\"s2\">GRS<\/span><span class=\"s1\">\u8207\u5176\u4ed6\u5354\u8b8a\u91cf\u7d50\u5408\uff0c\u4ee5\u63d0\u9ad8\u9810\u6e2c\u7cbe\u5ea6\u3002\u9019\u90e8\u5206\u5167\u5bb9\u770b\u5230\u4e86\u907a\u50b3\u5b78\u5728\u500b\u9ad4\u5316\u91ab\u7642\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\u3002\u7b2c\u56db\u5929\u5247\u5c08\u6ce8\u65bc\u5b5f\u5fb7\u723e\u96a8\u6a5f\u5316\uff08<\/span><span class=\"s2\">MR<\/span><span class=\"s1\">\uff09\u5206\u6790\uff0c\u5b78\u54e1\u5b78\u7fd2\u5982\u4f55\u900f\u904e\u516c\u958b\u6578\u64da\u8cc7\u6e90\u9032\u884c\u96d9\u6a23\u672c<\/span><span class=\"s2\">MR<\/span><span class=\"s1\">\u5206\u6790\uff0c\u4e26\u63a2\u8a0e\u907a\u50b3\u8b8a\u7570\u4f5c\u70ba\u5de5\u5177\u8b8a\u91cf\u4f86\u63a8\u65b7\u66b4\u9732\u56e0\u7d20\u8207\u7d50\u679c\u4e4b\u9593\u7684\u56e0\u679c\u95dc\u4fc2\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u6574\u500b\u5de5\u4f5c\u574a\u5f37\u8abf\u7406\u8ad6\u8207\u5be6\u8e10\u7684\u7dca\u5bc6\u7d50\u5408\uff0c\u6bcf\u65e5\u8ab2\u7a0b\u7686\u5305\u542b\u5927\u91cf\u7684\u5be6\u4f5c\u7df4\u7fd2\uff0c\u8b93\u5b78\u54e1\u80fd\u5920\u7acb\u5373\u904b\u7528\u6240\u5b78\u77e5\u8b58\u3002<\/span><span class=\"s2\">Prof. Harry Green <\/span><span class=\"s1\">\u8207\u52a9\u6559<\/span><span class=\"s2\"> Lu Jing-Zhan <\/span><span class=\"s1\">\u8a2d\u8a08\u7684\u6a21\u64ec\u6578\u64da\u96c6\u53ca\u8010\u5fc3\u6559\u5b78\uff0c\u4f7f\u5b78\u54e1\u5728\u5b78\u7fd2\u904e\u7a0b\u4e2d\u53d7\u76ca\u532a\u6dfa\u3002\u672c\u6b21\u8ab2\u7a0b\u4f7f\u7528\u7684\u5de5\u5177\u5305\u62ec<\/span><span class=\"s2\">PLINK<\/span><span class=\"s1\">\u3001<\/span><span class=\"s2\">R<\/span><span class=\"s1\">\u53ca\u591a\u7a2e\u5728\u7dda\u8cc7\u6e90\uff0c\u9019\u4e9b\u5747\u70ba\u7576\u524d\u907a\u50b3\u5b78\u7814\u7a76\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u3002\u900f\u904e\u5b78\u7fd2\uff0c\u5b78\u54e1\u4e0d\u50c5\u719f\u7df4\u638c\u63e1\u5de5\u5177\u4f7f\u7528\uff0c\u9084\u7406\u89e3\u4e86\u5176\u80cc\u5f8c\u7684\u539f\u7406\u8207\u9069\u7528\u5834\u666f\uff0c\u4e26\u8b93\u5b78\u54e1\u5c0d\u907a\u50b3\u5b78\u7814\u7a76\u6709\u4e86\u66f4\u5168\u9762\u7684\u8a8d\u8b58\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u5f9e<\/span><span class=\"s2\">GWAS<\/span><span class=\"s1\">\u5230<\/span><span class=\"s2\">GRS<\/span><span class=\"s1\">\uff0c\u518d\u5230<\/span><span class=\"s2\">MR<\/span><span class=\"s1\">\u5206\u6790\uff0c\u9019\u6b21\u5de5\u4f5c\u574a\u5b8c\u6574\u5448\u73fe\u907a\u50b3\u5b78\u5982\u4f55\u5f9e\u767c\u73fe\u75be\u75c5\u76f8\u95dc\u57fa\u56e0\uff0c\u5230\u8a55\u4f30\u500b\u9ad4\u98a8\u96aa\uff0c\u518d\u5230\u63a8\u65b7\u56e0\u679c\u95dc\u4fc2\u7684\u5b8c\u6574\u7814\u7a76\u6d41\u7a0b\u3002\u5b78\u54e1\u666e\u904d\u53cd\u6620\uff0c\u672c\u6b21\u5b78\u7fd2\u7d93\u9a57\u4e0d\u50c5\u63d0\u5347\u4e86\u5c08\u696d\u80fd\u529b\uff0c\u4e5f\u6fc0\u767c\u4e86\u5c0d\u907a\u50b3\u5b78\u7814\u7a76\u7684\u6fc3\u539a\u8208\u8da3\u3002\u9019\u662f\u4e00\u500b\u5167\u5bb9\u8c50\u5bcc\u4e14\u5be6\u7528\u6027\u6975\u9ad8\u7684\u907a\u50b3\u5b78\u9032\u968e\u8ab2\u7a0b\uff0c\u70ba\u5b78\u54e1\u63d0\u4f9b\u5805\u5be6\u7684\u7406\u8ad6\u57fa\u790e\u8207\u5be6\u52d9\u7d93\u9a57\uff0c\u76f8\u4fe1\u5c0d\u5b78\u54e1\u5011\u672a\u4f86\u7684\u5b78\u7fd2\u548c\u7814\u7a76\u6703\u7522\u751f\u6df1\u9060\u5f71\u97ff\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17883\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551.jpeg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551.jpeg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551-300x200.jpeg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551-768x512.jpeg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551-730x487.jpeg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551-435x290.jpeg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5551-272x182.jpeg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17884\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595.jpeg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595.jpeg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595-300x200.jpeg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595-768x512.jpeg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595-730x487.jpeg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595-435x290.jpeg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5595-272x182.jpeg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17885\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639.jpeg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639.jpeg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639-300x200.jpeg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639-768x512.jpeg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639-730x487.jpeg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639-435x290.jpeg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5639-272x182.jpeg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-17886\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670.jpeg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670.jpeg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670-300x200.jpeg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670-768x512.jpeg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670-730x487.jpeg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670-435x290.jpeg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2025\/02\/IMG_5670-272x182.jpeg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\/\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78\u751f\u7269\u91ab\u5b78\u66a8\u5de5\u7a0b\u7cfb \u6148\u6fdf\u5927\u5b78\u751f\u7269\u91ab\u5b78\u66a8\u5de5\u7a0b\u5b78 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":17883,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-17882","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/17882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17882"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/17882\/revisions"}],"predecessor-version":[{"id":17887,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/17882\/revisions\/17887"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/17883"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}