{"id":16652,"date":"2024-09-20T09:12:48","date_gmt":"2024-09-20T01:12:48","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=16652"},"modified":"2024-09-20T09:13:01","modified_gmt":"2024-09-20T01:13:01","slug":"%e5%be%b7%e5%9c%8b%e5%9c%8b%e5%ae%b6%e7%a7%91%e5%ad%b8%e9%99%a2%e5%a3%ab%e7%be%8e%e5%9c%8b%e5%be%b7%e5%b7%9e%e5%a4%a7%e5%ad%b8%e6%95%99%e6%8e%88%e8%92%9e%e8%87%a8%e6%85%88%e5%a4%a7%e4%ba%a4%e6%b5%81","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=16652","title":{"rendered":"\u5fb7\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u58eb&\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u6559\u6388\u849e\u81e8\u6148\u5927\u4ea4\u6d41\u8a0e\u8ad6"},"content":{"rendered":"

\u6587<\/span>\/<\/span>\u5716\uff1a\u6148\u6fdf\u5927\u5b78\u91ab\u5de5\u7cfb<\/span><\/p>\n

\u70ba\u4fc3\u9032\u672c\u6821\u8207\u570b\u969b\u91ab\u5de5\u9818\u57df\u7684\u5b78\u8853\u4ea4\u6d41\uff0c\u4e26\u4e14\u62d3\u5c55\u5e2b\u751f\u4e4b\u570b\u969b\u8996\u91ce\uff0c\u6148\u5927\u91ab\u5de5\u7cfb\u5f88\u69ae\u5e78\u65bc<\/span>113<\/span>\u5e74<\/span>8<\/span>\u6708<\/span>29<\/span>\u65e5\u9080\u8acb\u5230\u5fb7\u570b\u570b\u5bb6\u79d1\u5b78\u9662\u9662\u58eb\u66a8\u6155\u5c3c\u9ed1\u85e5\u7406\u5b78\u6559\u6388<\/span>– Martin Biel<\/span>\u4ee5\u53ca\u7f8e\u570b\u5fb7\u5dde\u5927\u5b78\u751f\u7269\u66a8\u85e5\u7406\u7cfb\u6559\u6388<\/span>– Michael Zhu<\/span>\u4f86\u64d4\u4efb\u91ab\u5de5\u7cfb<\/span>113<\/span>\u5b78\u5e74\u7b2c<\/span>1<\/span>\u5b78\u671f\u5c08\u984c\u8b1b\u5ea7\u7684\u8b1b\u8005\uff0c\u540c\u884c\u53f0\u5927\u9673\u653f\u5f70\u52a9\u7406\u6559\u6388\u64d4\u4efb\u6b64\u8b1b\u5ea7\u7684\u4e3b\u6301\u4eba\u3002\u5289\u6021\u5747\u6821\u9577\u9996\u5148\u5c0d\u65bc\u9060\u9053\u800c\u4f86\u7684\u8cb4\u8cd3\u8868\u793a\u6b61\u8fce\u53ca\u5341\u5206\u69ae\u5e78\u4ed6\u5011\u849e\u81e8\u6211\u6821\u9032\u884c\u6f14\u8b1b\u3002\u6f14\u8b1b\u6703\u5834\u9664\u4e86\u6148\u5927\u5e2b\u751f\u53c3\u8207\u5916\uff0c\u53f0\u5927\u91ab\u6280\u6240\u4e94\u4f4d\u5b78\u751f\u4e5f\u966a\u540c\u5b78\u7fd2\u8207\u4ea4\u6d41\u3002<\/span><\/p>\n

Martin Biel <\/span>\u9662\u58eb\u4e3b\u8981\u5206\u4eab\u7684\u8b1b\u984c\u70ba<\/span>Ocular Gene Therapy- The rocky road from bench to bed side<\/span>\uff0c\u6982\u8ff0\u4e86<\/span>Martin Biel<\/span>\u9662\u58eb\u7684\u7814\u7a76\u5718\u968a\u82b1\u4e86\u6578\u5341\u5e74\u7684\u52aa\u529b\uff0c\u5229\u7528\u57fa\u56e0\u7642\u6cd5\u4f86\u6cbb\u7642\u773c\u90e8\u7684\u75be\u75c5\u3002<\/span>Martin Biel <\/span>\u9662\u58eb\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe<\/span>CNGA3 channel<\/span>\u7684\u7a81\u8b8a\u6703\u5c0e\u81f4\u60a3\u8005\u7372\u5f97<\/span>achromatopsia<\/span>\u7684\u75be\u75c5\u3002\u6b64\u75be\u75c5\u6703\u5c0e\u81f4\u60a3\u8005\u8272\u76f2\u3001\u8996\u529b\u5dee\u3001\u754f\u5149\u53ca\u773c\u7403\u9707\u986b\u7684\u81e8\u5e8a\u73fe\u8c61\u3002\u4ed6\u5011\u5617\u8a66\u4e86\u5229\u7528<\/span>lentivirus <\/span>\u6cbb\u7642\u6cd5\uff0c\u4f46\u7d50\u679c\u78ba\u5be6\u7121\u6548\u7684\u3002\u4e4b\u5f8c\u4ed6\u5011\u9078\u64c7<\/span>recombinant AAVs vector<\/span>\u4f86\u9032\u884c\u6cbb\u7642\uff0c\u767c\u73fe\u9019\u500b\u65b9\u6cd5\u78ba\u5be6\u53ef\u884c\u3002\u5728\u7d93\u904e\u4ed6\u5011\u8f9b\u52e4\u7814\u7a76\u5f8c\uff0c\u7d42\u65bc\u5728\u81e8\u5e8a\u6cbb\u7642\u4e0a\u5f9e\u773c\u75be\u60a3\u8005\u8eab\u4e0a\u5f97\u5230\u4e86\u6b63\u56de\u994b\uff0c\u70ba\u91ab\u7642\u754c\u505a\u51fa\u4e86\u4e00\u5927\u8ca2\u737b\u3002<\/span><\/p>\n

\u00a0\u00a0 \u00a0 <\/span>Michael Zhu<\/span>\u6559\u6388\u7684\u6f14\u8b1b\u8b1b\u984c\u70ba<\/span>Regulation and Function of Lysosomal Two-Pore Channels<\/span>\u3002<\/span>Michael Zhu<\/span>\u6559\u6388\u628a\u4ed6\u7684\u6f14\u8b1b\u7e3d\u7d50\u6210<\/span>4<\/span>\u9ede\uff1a<\/span><\/p>\n

    \n
  1. \u5728<\/span>endolysosomes<\/span>\u7684\u96d9\u5b54\u901a\u9053\uff08<\/span>TPCs<\/span>\uff09\u6709\u591a\u7a2e\u529f\u80fd\u3002<\/span><\/li>\n
  2. TPCs<\/span>\u6703\u5c0d<\/span>PI(3,5)P2(nM-\u00a0\u00b5M)<\/span>\u548c<\/span>NAADP<\/span>\uff08<\/span>nM<\/span>\uff09\u7522\u751f\u53cd\u61c9\u5f8c\u5f9e<\/span>endolysosomal store<\/span>\u91cb\u653e<\/span>Na<\/span>+<\/sup><\/span>\u548c<\/span>Ca<\/span>2+<\/sup><\/span> \u3002<\/span><\/li>\n
  3. TPC2<\/span>\u5c0d\u8abf\u7bc0<\/span>lysosome<\/span>\u548c<\/span>melanosome<\/span>\u7684<\/span>pH<\/span>\u503c\u4ee5\u53ca\u9ed1\u8272\u7d20\u7684\u751f\u6210\uff0c\u9032\u800c\u5f71\u97ff\u76ae\u819a\u548c\u982d\u767c\u7684\u984f\u8272\uff1b<\/span>R210<\/span>\u5c0d\u65bc<\/span>TPC2<\/span>\u4e4b<\/span>phosphoinositides<\/span>\u7684\u654f\u611f\u6027\u5f88\u91cd\u8981\uff0c\u5176\u7a81\u8b8a\u6210<\/span>cysteine<\/span>\u6703\u9020\u6210\u4eba\u985e<\/span>TPC2<\/span>\u901a\u9053\u7684\u6d3b\u5316\u53ca\u6703\u5c0e\u81f4\u767d\u5316\u75c5\u3002<\/span><\/li>\n
  4. TPCs<\/span>\u53c3\u8207\u652f\u6301<\/span>endolysosomes<\/span>\u7684\u7ba1\u6a23\u7d50\u69cb\u751f\u6210\uff0c\u800c\u53ef\u80fd\u6703\u5c0e\u81f4\u5b83\u5011\u5f71\u97ff\u56ca\u6ce1\u904b\u8f38\u548c\u75c5\u6bd2\u611f\u67d3\u3002\u7136\u800c\u5176\u4e2d\u7684\u6a5f\u5236\u4ecd\u6709\u5f85\u91d0\u6e05\u3002<\/span><\/li>\n<\/ol>\n

    \u9019\u5169\u5834\u6f14\u8b1b\uff0c\u5e2b\u751f\u5011\u90fd\u5f88\u8a8d\u8046\u807d\u53ca\u8e34\u8e8d\u767c\u554f\uff0c\u8b1b\u8005\u5011\u4e5f\u4e0d\u53ad\u5176\u7169\u5730\u7528\u81ea\u5df1\u7684\u5c08\u696d\u77e5\u8b58\u56de\u61c9\u554f\u984c\uff0c\u6821\u9577\u540c\u6642\u5411<\/span>Martin Biel <\/span>\u9662\u58eb\u5206\u4eab\u6148\u6fdf\u57fa\u91d1\u6703\u5728\u83f2\u5f8b\u8cd3\u6709\u505a\u8a31\u591a\u7fa9\u8a3a\uff0c\u7279\u5225\u6709\u4e9b\u773c\u75be\u60a3\u8005\uff0c\u82e5\u672a\u4f86\u6709\u6a5f\u6703\u53ef\u518d\u591a\u4ea4\u6d41\u53d6\u7d93\u3002<\/span>\u63a5\u8457\u8a31\u9662\u9577\u5e36\u8cb4\u8cd3\u5011\u53ca\u53f0\u5927\u7684\u5e2b\u751f\u81f3\u6a21\u64ec\u91ab\u5b78\u4e2d\u5fc3\u9032\u884c\u53c3\u8a2a\uff0c\u8207\u6703\u8cb4\u8cd3\u5c0d\u6148\u6fdf\u7684\u89e3\u5256\u4eba\u6587\u6559\u80b2\u7559\u4e0b\u6df1\u523b\u7684\u5370\u8c61\u3002<\/span>\u5348\u9910\u4ea4\u6d41\u4e4b\u5f8c\uff0c\u5169\u6821\u7814\u7a76\u751f\u9032\u884c\u7814\u7a76\u9032\u5ea6\u5831\u544a\uff0c\u7531\u4e8c\u4f4d\u8b1b\u8005\u7d66\u4e88\u7814\u7a76\u6307\u5c0e\u53ca\u7d93\u9a57\u5206\u4eab\uff0c\u63d0\u4f9b\u5b78\u751f\u826f\u597d\u7684\u5efa\u8b70\u53ca\u5b78\u7fd2\u7684\u6a5f\u6703\u3002<\/span><\/p>\n

    \u672c\u6b21\u6d3b\u52d5\u7531\u53f0\u5927\u91ab\u6280\u6240\u8207\u6148\u5927\u91ab\u5de5\u7cfb\u5408\u4f5c\u8fa6\u7406\uff0c\u5e2b\u751f\u85c9\u7531\u5408\u4f5c\u589e\u76ca\u5b78\u8853\u9023\u7d50\uff0c\u540c\u6642\u900f\u904e\u5916\u7c4d\u5b78\u8005\u4e4b\u4f86\u8a2a\u5206\u4eab\uff0c\u63d0\u4f9b\u672c\u6821\u5e2b\u751f\u8207\u570b\u969b\u5c08\u696d\u4eba\u58eb\u7684\u4ea4\u6d41\u6a5f\u6703\uff0c\u958b\u95ca\u570b\u969b\u8996\u91ce\uff0c\u800c\u6b64\u884c\u5916\u8cd3\u4e5f\u5c0d\u672c\u6821\u7684\u4eba\u6587\u8207\u5c08\u696d\u6559\u80b2\u7559\u4e0b\u6df1\u523b\u7684\u5370\u8c61\uff0c\u8868\u9054\u672a\u4f86\u6709\u6a5f\u6703\u5c07\u8207\u672c\u6821\u9032\u884c\u66f4\u9032\u4e00\u6b65\u7684\u5b78\u8853\u5408\u4f5c\u3002<\/span><\/p>\n

    \"\" \"\" \"\" \"\"<\/p>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    \u6587\/\u5716\uff1a\u6148\u6fdf\u5927\u5b78\u91ab\u5de5\u7cfb \u70ba\u4fc3\u9032\u672c\u6821\u8207\u570b\u969b\u91ab\u5de5\u9818\u57df\u7684\u5b78\u8853\u4ea4\u6d41\uff0c […]<\/p>\n","protected":false},"author":3,"featured_media":16655,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-16652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16652"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16652\/revisions"}],"predecessor-version":[{"id":16657,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16652\/revisions\/16657"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/16655"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}