{"id":16300,"date":"2024-07-26T17:12:17","date_gmt":"2024-07-26T09:12:17","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=16300"},"modified":"2024-07-26T17:12:17","modified_gmt":"2024-07-26T09:12:17","slug":"%e5%9c%8b%e5%ae%b6%e8%a1%9b%e7%94%9f%e7%a0%94%e7%a9%b6%e9%99%a2%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e6%89%80%e6%9d%8e%e5%b2%b3%e5%80%ab%e7%a0%94%e7%a9%b6%e5%93%a1%e5%88%86%e4%ba%ab%e8%85%ab%e7%98%a4","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=16300","title":{"rendered":"\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u764c\u75c7\u7814\u7a76\u6240\u674e\u5cb3\u502b\u7814\u7a76\u54e1\u5206\u4eab\u816b\u7624\u5fae\u74b0\u5883\u4e0b\u7684\u7c92\u7dda\u9ad4\u8a0a\u865f\u8655\u7406\u7cfb\u7d71\u8207\u764c\u75c7\u6cbb\u7642\u65b0\u7b56\u7565"},"content":{"rendered":"<p class=\"p1\"><span class=\"s1\">\u6587<\/span><span class=\"s2\">\/<\/span><span class=\"s1\">\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u7406\u5b78\u79d1<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u7406\u5b78\u79d1\u53ca\u751f\u7269\u91ab\u5b78\u78a9\u58eb\u73ed\u9080\u8acb\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u764c\u75c7\u7814\u7a76\u6240\u517c\u4efb\u5b78\u8853\u767c\u5c55\u8655\u526f\u8655\u9577\u7684\u674e\u5cb3\u502b\u535a\u58eb\u849e\u81e8\u6f14\u8b1b\uff0c\u674e\u535a\u58eb\u6df1\u5165\u63a2\u8a0e\u4e86\u5176\u7814\u7a76\u9818\u57df\u7684\u6700\u65b0\u9032\u5c55\uff0c\u6f14\u8b1b\u4e3b\u984c\u70ba\u300c<\/span><span class=\"s2\">The ER-Mitochondria Contacts Trigger Ca2+-dependent Mitophagy: A Mitochondrial Signaling Processing System in Hypoxic Tumor Microenvironment<\/span><span class=\"s1\">\u300d\u3002\u674e\u535a\u58eb\u5f9e\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u7684\u767c\u5c55\u958b\u59cb\u8b1b\u8d77\uff0c\u4ecb\u7d39\u5728\u6b64\u9818\u57df\u6709\u5353\u8d8a\u8ca2\u737b\u4e26\u7372\u5f97\u8afe\u8c9d\u723e\u751f\u91ab\u734e\u7684<\/span><span class=\"s2\"> James P. Allison<\/span><span class=\"s1\">\u6559\u6388\u8207<\/span><span class=\"s2\">Tasuku Honjo<\/span><span class=\"s1\">\u6559\u6388\u7684\u6545\u4e8b\uff0c\u5e36\u9818\u6211\u5011\u6df1\u5165\u63a2\u8a0e\u7c92\u7dda\u9ad4\u5728\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u89d2\u8272\uff0c\u7279\u5225\u662f\u5728\u764c\u75c7\u514d\u75ab\u9003\u812b\u6a5f\u5236\u548c\u6cbb\u7642\u7b56\u7565\u4e2d\u7684\u61c9\u7528\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u674e\u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u9577\u671f\u4ee5\u4f86\u5c08\u6ce8\u65bc\u63a2\u7d22\u7f3a\u6c27\u548c\u7c92\u7dda\u9ad4\u6c27\u5316\u58d3\u529b\u5728\u764c\u75c7\u6cbb\u7642\u4e2d\u7684\u5f71\u97ff\u3002\u6f14\u8b1b\u4e2d\uff0c\u4ed6\u5011\u6df1\u5165\u63a2\u8a0e\u4e86\u7c92\u7dda\u9ad4<\/span><span class=\"s2\">Lon<\/span><span class=\"s1\">\u4f34\u8b77\u58d3\u529b\u86cb\u767d\u5728\u7f3a\u6c27\u548c\u6975\u7aef\u6c27\u5316\u58d3\u529b\u4e0b\u5982\u4f55\u4fc3\u9032\u816b\u7624\u7684\u767c\u5c55\u548c\u8840\u7ba1\u65b0\u751f\uff0c\u4ee5\u53ca\u9019\u4e9b\u904e\u7a0b\u5982\u4f55\u76f4\u63a5\u5f71\u97ff\u514d\u75ab\u767c\u708e\u53cd\u61c9\u7684\u8abf\u63a7\u3002\u6b64\u5916\uff0c\u674e\u535a\u58eb\u9084\u4ecb\u7d39\u4e86\u4ed6\u5011\u5718\u968a\u5728\u5229\u7528\u7c92\u7dda\u9ad4<\/span><span class=\"s2\">DNA(mtDNA)<\/span><span class=\"s1\">\u91cb\u653e\u548c\u767c\u708e\u7d30\u80de\u6fc0\u7d20\u5206\u6ccc\u65b9\u9762\u7684\u6700\u65b0\u7814\u7a76\u9032\u5c55\uff0c\u9019\u4e9b\u7814\u7a76\u6210\u679c\u5c0d\u65bc\u7406\u89e3\u764c\u75c7\u7d30\u80de\u5982\u4f55\u9003\u907f\u514d\u75ab\u76e3\u63a7\u5177\u6709\u91cd\u8981\u610f\u7fa9\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u5728\u85e5\u7269\u958b\u767c\u65b9\u9762\uff0c\u674e\u535a\u58eb\u63d0\u5230\u4ed6\u5011\u5718\u968a\u6b63\u4ee5\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684\u8840\u7ba1\u65b0\u751f\u548c\u514d\u75ab\u9003\u812b\u6a5f\u5236\u70ba\u57fa\u790e\uff0c\u958b\u767c\u65b0\u578b\u764c\u75c7\u6cbb\u7642\u7b56\u7565\u3002\u7279\u5225\u662f\u901a\u904e\u8840\u7ba1\u6b63\u5e38\u5316\u7684\u7b56\u7565\uff0c\u4ed6\u5011\u81f4\u529b\u65bc\u767c\u73fe\u548c\u958b\u767c\u80fd\u5920\u6709\u6548\u63a7\u5236\u816b\u7624\u751f\u9577\u548c\u6539\u5584\u75c5\u4eba\u751f\u6d3b\u8cea\u91cf\u7684\u85e5\u7269\u3002<\/span><\/p>\n<p class=\"p2\"><span class=\"s1\">\u6f14\u8b1b\u73fe\u5834\uff0c\u5e2b\u751f\u5011\u7a4d\u6975\u53c3\u8207\uff0c\u63d0\u51fa\u4e86\u8a31\u591a\u6df1\u5165\u7684\u554f\u984c\uff0c\u8207\u674e\u535a\u58eb\u5c55\u958b\u4e86\u71b1\u70c8\u7684\u8a0e\u8ad6\u548c\u4ea4\u6d41\u3002\u9019\u6b21\u6f14\u8b1b\u4e0d\u50c5\u70ba\u73fe\u5834\u89c0\u773e\u5e36\u4f86\u4e86\u65b0\u77e5\u8b58\uff0c\u4e5f\u70ba\u672a\u4f86\u764c\u75c7\u6cbb\u7642\u7684\u767c\u5c55\u958b\u555f\u4e86\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\uff0c\u671f\u5f85\u9019\u4e9b\u7814\u7a76\u6210\u679c\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\u8f49\u5316\u70ba\u5177\u9ad4\u7684\u81e8\u5e8a\u61c9\u7528\uff0c\u70ba\u75c5\u4eba\u5e36\u4f86\u66f4\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6cd5\u3002<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16301\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410830_0-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16302\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410833_0.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410833_0.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/410833_0-300x200.jpg 300w, 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100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16306\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336.jpg\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336-300x169.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336-768x432.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336-730x411.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_122336-435x245.jpg 435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16307\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055.jpg\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055-300x169.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055-768x432.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055-730x411.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131055-435x245.jpg 435w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16308\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131638.jpg\" alt=\"\" width=\"1024\" height=\"576\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131638.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131638-300x169.jpg 300w, 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https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131845-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_131845-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-16310\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/07\/20240611_132018-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\/\u7167\u7247\uff1a\u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u7406\u5b78\u79d1 \u6148\u6fdf\u5927\u5b78\u91ab\u5b78\u7cfb\u751f\u7406\u5b78\u79d1\u53ca\u751f [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":16306,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-16300","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16300"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16300\/revisions"}],"predecessor-version":[{"id":16311,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/16300\/revisions\/16311"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/16306"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16300"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16300"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}