{"id":15030,"date":"2024-02-05T16:36:37","date_gmt":"2024-02-05T08:36:37","guid":{"rendered":"https:\/\/newsletter.tcu.edu.tw\/?p=15030"},"modified":"2024-02-05T16:36:37","modified_gmt":"2024-02-05T08:36:37","slug":"%e6%85%88%e5%a4%a7%e5%9c%98%e9%9a%8a%e7%a0%94%e7%a9%b6%e6%ba%b6%e9%85%b6%e9%ab%94%e5%8f%83%e8%88%87%e8%97%a5%e7%89%a9%e8%80%90%e5%8f%97%e6%80%a7-%e8%a1%80%e7%99%8c%e6%a8%a1%e5%bc%8f","status":"publish","type":"post","link":"https:\/\/newsletter.tcu.edu.tw\/?p=15030","title":{"rendered":"\u6148\u5927\u5718\u968a\u7814\u7a76\u6eb6\u9176\u9ad4\u53c3\u8207\u85e5\u7269\u8010\u53d7\u6027-\u8840\u764c\u6a21\u5f0f"},"content":{"rendered":"<p class=\"p2\"><span class=\"s1\">\u6587:\u8449\u7da0\u8212<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u5927\u5bb6\u5c0d\u767d\u8840\u75c5\u61c9\u8a72\u90fd\u4e0d\u964c\u751f\uff01\u767d\u8840\u75c5\uff08\u6216\u7a31\u8840\u764c\uff09\u662f\u4e00\u7a2e\u5f71\u97ff\u8840\u6db2\u548c\u9aa8\u9ad3\u7684\u764c\u75c7\uff0c\u7279\u9ede\u662f\u9aa8\u9ad3\u7522\u751f\u904e\u591a\u7684\u7570\u5e38\u767d\u8840\u7403\u3002\u9019\u4e9b\u7570\u5e38\u767d\u8840\u7403\uff08\u7a31\u70ba\u8840\u764c\u7d30\u80de\uff09\u7121\u6cd5\u6b63\u5e38\u904b\u4f5c\uff0c\u4e5f\u4e0d\u80fd\u53d6\u4ee3\u6b63\u5e38\u767d\u8840\u7403\u7684\u514d\u75ab\u529f\u80fd\uff0c\u56e0\u800c\u5c0e\u81f4\u591a\u7a2e\u5065\u5eb7\u554f\u984c\u3002\u767d\u8840\u75c5\u53ef\u4ee5\u5206\u70ba\u5e7e\u7a2e\u4e0d\u540c\u7684\u985e\u578b\uff0c\u4e3b\u8981\u6839\u64da\u5b83\u662f\u6025\u6027\u9084\u662f\u6162\u6027\uff0c\u4ee5\u53ca\u5f71\u97ff\u7684\u767d\u8840\u7403\u985e\u578b\uff08\u6dcb\u5df4\u7cfb\u6216\u9ad3\u7cfb\uff09\u4f86\u5340\u5206\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u767d\u8840\u75c5\u7684\u75c7\u72c0\u53ef\u80fd\u5305\u62ec\u75b2\u5026\u3001\u7121\u6545\u7600\u50b7\u3001\u767c\u71b1\u3001\u9ad4\u91cd\u6e1b\u8f15\u3001\u9aa8\u982d\u6216\u95dc\u7bc0\u75bc\u75db\u3001\u53cd\u8986\u767c\u751f\u611f\u67d3\u7b49\u3002\u8a3a\u65b7\u901a\u5e38\u9700\u8981\u901a\u904e\u8840\u6db2\u6aa2\u67e5\u548c\u9aa8\u9ad3\u6aa2\u67e5\u4f86\u78ba\u5b9a\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u6cbb\u7642\u65b9\u6cd5\u53d6\u6c7a\u65bc\u767d\u8840\u75c5\u7684\u985e\u578b\u548c\u60a3\u8005\u7684\u5176\u4ed6\u5065\u5eb7\u72c0\u6cc1\uff0c\u53ef\u80fd\u5305\u62ec\u5316\u7642\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3001\u9776\u5411\u85e5\u7269\u6cbb\u7642\u3001\u514d\u75ab\u7642\u6cd5\u548c\uff08\u5728\u67d0\u4e9b\u60c5\u6cc1\u4e0b\uff09\u9aa8\u9ad3\u79fb\u690d\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u4f46\u662f\uff0c\u764c\u7d30\u80de\u6709\u80fd\u529b\u767c\u5c55\u51fa\u6297\u85e5\u6027\u3002\u5c0d\u75c5\u4eba\u4f86\u8aaa\uff0c\u6cbb\u7642\u7684\u53cd\u61c9\u53ca\u9078\u64c7\u90fd\u6703\u53d7\u5230\u9650\u5236\uff0c\u751f\u6d3b\u54c1\u8cea\u4e5f\u5927\u53d7\u5f71\u97ff\u3002\u56e0\u6b64\uff0c\u5fc5\u9808\u5f97\u8a2d\u6cd5\u958b\u767c\u51fa\u80fd\u6291\u5236\u6297\u85e5\u80fd\u529b\u7684\u6cbb\u7642\u65b9\u6cd5\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u904e\u53bb\u7684\u7814\u7a76\u767c\u73fe\uff0c\u6709\u4e9b\u764c\u7d30\u80de\u5c0d\u5316\u7642\u53ca\u9776\u5411\u85e5\u7269\u7522\u751f\u6297\u6027\u662f\u4f86\u81ea\u65bc\u5b83\u7684\u6eb6\u9176\u9ad4\u3002\u6eb6\u9176\u9ad4\uff08<\/span><span class=\"s2\">lysosome<\/span><span class=\"s1\">\uff09\u662f\u7d30\u80de\u5167\u7684\u4e00\u7a2e\u9178\u6027\u80de\u5668\uff0c\u5c0d\u65bc\u7d30\u80de\u5167\u7269\u8cea\u7684\u6d88\u5316\u548c\u6e05\u7406\u81f3\u95dc\u91cd\u8981\uff0c\u4e5f\u64d4\u4efb\u6536\u96c6\u80de\u5167\u6709\u5bb3\u7269\u8cea\u7684\u89d2\u8272\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u6148\u6fdf\u5927\u5b78\u5206\u5b50\u751f\u7269\u66a8\u4eba\u985e\u907a\u50b3\u5b78\u7cfb\u7684\u8607\u6dd1\u60e0\u8001\u5e2b\uff0c\u5c0d\u764c\u75c7\u76f8\u95dc\u7684\u75c5\u7406\u53ca\u85e5\u7406\u6a5f\u5236\u4e00\u76f4\u90fd\u5728\u95dc\u6ce8\uff0c\u6700\u8fd1\u5979\u7684\u7814\u7a76\u805a\u7126\u65bc\u6c2f\u55b9\uff08<\/span><span class=\"s2\">Chloroquine<\/span><span class=\"s1\">\uff09\u5c0d\u767d\u8840\u75c5\u7d30\u80de\u7684\u4f5c\u7528\u3002\u6c2f\u55b9\u662f\u4e00\u7a2e\u5df2\u7d93\u4f7f\u7528\u4e86\u8d85\u904e70\u5e74\u7684\u85e5\u7269\uff0c\u56e0\u5176\u80fd\u6291\u5236\u6eb6\u9176\u9ad4\u7684\u4f5c\u7528\uff0c\u7528\u4f86\u6cbb\u7642\u7627\u75be\u539f\u87f2\u611f\u67d3\u3002\u904e\u53bb\u5728\u975e\u6d32\u7627\u75be\u6d41\u884c\u5730\u5340\u7684\u6c2f\u55b9\u6295\u8207\uff0c\u767c\u73fe\u6dcb\u5df4\u764c\u767c\u75c5\u7387\u4e5f\u8ddf\u8457\u964d\u4f4e! <\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u8607\u8001\u5e2b\u4ee5\u8840\u764c\u7d30\u80de\u682aK562\u70ba\u6a21\u5f0f\uff0c\u6e2c\u8a66\u5b83\u5c0d\u6c2f\u55b9\u7684\u53cd\u61c9\uff0c\u767c\u73fe\u5728\u6c2f\u55b9\u7684\u4f5c\u7528\u4e0b\u8840\u764c\u7d30\u80de\u6703\u8a66\u5716\u8abf\u7bc0\u5176\u5167\u90e8\u9178\u5ea6\u4ee5\u9069\u61c9\u85e5\u7269\u7684\u5f71\u97ff\u3002\u4f8b\u5982\uff0c\u7576\u8840\u764c\u7d30\u80de\u66b4\u9732\u65bc\u4f4e\u5291\u91cf\u7684\u6c2f\u55b9\uff08<\/span><span class=\"s2\">5-10 \u03bcM<\/span><span class=\"s1\">\uff09\u6642\uff0c\u6703\u7522\u751f\u66f4\u591a\u7684\u9178\u6027\u80de\u5668\uff08\u4e5f\u5c31\u662f\u6eb6\u9176\u9ad4\uff09\u4f86\u9069\u61c9\u85e5\u7269\u7684\u5f71\u97ff\uff1b\u800c\u5728\u9ad8\u5291\u91cf\uff08<\/span><span class=\"s2\">20<\/span><span class=\"s1\">\u81f3<\/span><span class=\"s2\">80 \u03bcM<\/span><span class=\"s1\">\uff09\u4e0b\uff0c\u5247\u53ef\u80fd\u5c0e\u81f4\u7d30\u80de\u505c\u6b62\u589e\u751f\u4e26\u6700\u7d42\u6b7b\u4ea1\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u6c2f\u55b9\u80fd\u5920\u589e\u52a0\u7d30\u80de\u5167\u7684\u6c27\u5316\u58d3\u529b\uff0c\u9019\u5c0d\u65bc\u7d30\u80de\u7684\u751f\u5b58\u548c\u6b7b\u4ea1\u6709\u91cd\u8981\u5f71\u97ff\u3002\u8607\u8001\u5e2b\u7684\u7814\u7a76\u986f\u793a\uff0c\u8655\u7406\u5f8c\u7684\u7d30\u80de\u6703\u589e\u52a0\u7c92\u7dda\u9ad4\u7684\u6578\u91cf\uff0c\u9019\u53ef\u80fd\u662f\u5c0d\u6c27\u5316\u58d3\u529b\u7684\u4e00\u7a2e\u9069\u61c9\u8abf\u7bc0\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u9019\u7bc7\u7814\u7a76\u986f\u793a\u4e86\u6c2f\u55b9\u5982\u4f55\u901a\u904e\u6539\u8b8a\u6eb6\u9176\u9ad4\u548c\u7d30\u80de\u5167\u90e8\u74b0\u5883\u4f86\u5f71\u97ff\u8840\u764c\u7d30\u80de\uff0c\u4e5f\u6307\u51fa\u91dd\u5c0d\u6eb6\u9176\u9ad4\u6cbb\u7642\u7684\u512a\u9ede\u8207\u7f3a\u9ede\uff0c\u4f7f\u6211\u5011\u66f4\u77ad\u89e3\u764c\u7d30\u80de\u7684\u6297\u85e5\u80fd\u529b\u53ca\u5176\u6975\u9650\u3002<\/span><\/p>\n<p class=\"p3\"><span class=\"s1\">\u53c3\u8003\u6587\u737b\uff1a<\/span><\/p>\n<p class=\"p5\"><span class=\"s1\">Su SH, Su SJ, Huang LY, Chiang YC. Leukemic cells resist lysosomal inhibition through the mitochondria-dependent reduction of intracellular pH and oxidants. Free Radic Biol Med. 2023 Mar;198:1-11. doi: 10.1016\/j.freeradbiomed.2023.01.025. Epub 2023 Jan 31. PMID: 36736442.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-15031\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/DSC027511-1-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-15032\" src=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0.jpg\" alt=\"\" width=\"1024\" height=\"683\" srcset=\"https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0.jpg 1024w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0-300x200.jpg 300w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0-768x512.jpg 768w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0-730x487.jpg 730w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0-435x290.jpg 435w, https:\/\/newsletter.tcu.edu.tw\/wp-content\/uploads\/2024\/02\/S__32382994_0-272x182.jpg 272w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6587:\u8449\u7da0\u8212 \u5927\u5bb6\u5c0d\u767d\u8840\u75c5\u61c9\u8a72\u90fd\u4e0d\u964c\u751f\uff01\u767d\u8840\u75c5\uff08\u6216\u7a31\u8840\u764c\uff09\u662f\u4e00 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":15032,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-15030","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5","clearfix"],"_links":{"self":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/15030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15030"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/15030\/revisions"}],"predecessor-version":[{"id":15033,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/posts\/15030\/revisions\/15033"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=\/wp\/v2\/media\/15032"}],"wp:attachment":[{"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.tcu.edu.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}